Stille/diels-alder reaction sequences: Diversity-oriented access to novel steroids

Hans Wolf Sunnemann; Anja Hofmeister; Jörg Magull; Martin G. Banwell; Armin De Meijere

doi:10.1021/ol062878m

Stille/diels-alder reaction sequences: Diversity-oriented access to novel steroids

Hans Wolf Sunnemann, Anja Hofmeister, Jörg Magull, Martin G. Banwell, Armin De Meijere^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

An efficient, diversity-oriented approach to novel steroid analogues possessing a C-5β configuration begins with the Stille cross-coupling of enantiomerically pure cycloalkenylstannane trans-2 and enol triflate 3. The resulting diene trans-4 engages in Diels-Alder cycloaddition reactions with a range of dienophiles to give, after removal of protecting groups, biologically interesting 6,7-disubstituted steroid analogues.

Original language	English
Pages (from-to)	517-520
Number of pages	4
Journal	Organic Letters
Volume	9
Issue number	3
DOIs	https://doi.org/10.1021/ol062878m
Publication status	Published - 1 Feb 2007

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10.1021/ol062878m

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abstract = "An efficient, diversity-oriented approach to novel steroid analogues possessing a C-5β configuration begins with the Stille cross-coupling of enantiomerically pure cycloalkenylstannane trans-2 and enol triflate 3. The resulting diene trans-4 engages in Diels-Alder cycloaddition reactions with a range of dienophiles to give, after removal of protecting groups, biologically interesting 6,7-disubstituted steroid analogues.",

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AU - Banwell, Martin G.

AU - De Meijere, Armin

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Stille/diels-alder reaction sequences: Diversity-oriented access to novel steroids

Abstract

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