Stimulation of dengue virus replication in cultured Aedes albopictus (C6/36) mosquito cells by the antifungal imidazoles ketoconazole and miconazole

E. Lee, K. McLean, R. C. Weir, L. Dalgarno

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Replication of dengue type 3 virus in Aedes albopictus C6/36 cells was enhanced more than 50-fold by addition of the antifungal imidazole derivative ketoconazole within the first 4 h of infection. The stimulatory effect was reflected in the yield of infectious virus and in levels of viral RNA and protein synthesis. Enhanced yields were observed also for other flaviviruses, including dengue type 2 virus and Murray Valley encephalitis virus. Increased yields of dengue type 3 virus were not observed in African green monkey kidney (Vero) cells, human monocytic (U-937) cells, or cells of the mosquito Toxorhynchites amboinensis (TRA-171). (C) 2000 Academic Press.

    Original languageEnglish
    Pages (from-to)1-6
    Number of pages6
    JournalVirology
    Volume269
    Issue number1
    DOIs
    Publication statusPublished - 30 Mar 2000

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