Streptococcus makes the cut: Gasdermin A-induced pyroptosis

Anyang Zhao, Max Kirkby, Si Ming Man*

*Corresponding author for this work

    Research output: Contribution to journalComment/debatepeer-review

    4 Citations (Scopus)

    Abstract

    The gasdermin family of cell death executor proteins are activated by different proteases under different physiological conditions. A recent study by Deng et al. in Nature revealed that the cysteine protease SpeB from the human pathogen Streptococcus pyogenes directly cleaves and activates Gasdermin A to induce pyroptosis in skin cells.

    Original languageEnglish
    Pages (from-to)410-412
    Number of pages3
    JournalCell Host and Microbe
    Volume30
    Issue number4
    DOIs
    Publication statusPublished - 13 Apr 2022

    Fingerprint

    Dive into the research topics of 'Streptococcus makes the cut: Gasdermin A-induced pyroptosis'. Together they form a unique fingerprint.

    Cite this