Streptococcus makes the cut: Gasdermin A-induced pyroptosis

Anyang Zhao, Max Kirkby, Si Ming Man*

*Corresponding author for this work

    Research output: Contribution to journalComment/debatepeer-review

    4 Citations (Scopus)


    The gasdermin family of cell death executor proteins are activated by different proteases under different physiological conditions. A recent study by Deng et al. in Nature revealed that the cysteine protease SpeB from the human pathogen Streptococcus pyogenes directly cleaves and activates Gasdermin A to induce pyroptosis in skin cells.

    Original languageEnglish
    Pages (from-to)410-412
    Number of pages3
    JournalCell Host and Microbe
    Issue number4
    Publication statusPublished - 13 Apr 2022


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