Streptococcus makes the cut: Gasdermin A-induced pyroptosis

Anyang Zhao; Max Kirkby; Si Ming Man

doi:10.1016/j.chom.2022.03.003

Streptococcus makes the cut: Gasdermin A-induced pyroptosis

Anyang Zhao, Max Kirkby, Si Ming Man^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

10 Citations (Scopus)

Abstract

The gasdermin family of cell death executor proteins are activated by different proteases under different physiological conditions. A recent study by Deng et al. in Nature revealed that the cysteine protease SpeB from the human pathogen Streptococcus pyogenes directly cleaves and activates Gasdermin A to induce pyroptosis in skin cells.

Original language	English
Pages (from-to)	410-412
Number of pages	3
Journal	Cell Host and Microbe
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2022.03.003
Publication status	Published - 13 Apr 2022

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10.1016/j.chom.2022.03.003

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@article{b1f430dc13a349188109bdd5a4960e4e,

title = "Streptococcus makes the cut: Gasdermin A-induced pyroptosis",

abstract = "The gasdermin family of cell death executor proteins are activated by different proteases under different physiological conditions. A recent study by Deng et al. in Nature revealed that the cysteine protease SpeB from the human pathogen Streptococcus pyogenes directly cleaves and activates Gasdermin A to induce pyroptosis in skin cells.",

author = "Anyang Zhao and Max Kirkby and Man, \{Si Ming\}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = apr,

day = "13",

doi = "10.1016/j.chom.2022.03.003",

language = "English",

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T1 - Streptococcus makes the cut

T2 - Gasdermin A-induced pyroptosis

AU - Zhao, Anyang

AU - Kirkby, Max

AU - Man, Si Ming

PY - 2022/4/13

Y1 - 2022/4/13

N2 - The gasdermin family of cell death executor proteins are activated by different proteases under different physiological conditions. A recent study by Deng et al. in Nature revealed that the cysteine protease SpeB from the human pathogen Streptococcus pyogenes directly cleaves and activates Gasdermin A to induce pyroptosis in skin cells.

AB - The gasdermin family of cell death executor proteins are activated by different proteases under different physiological conditions. A recent study by Deng et al. in Nature revealed that the cysteine protease SpeB from the human pathogen Streptococcus pyogenes directly cleaves and activates Gasdermin A to induce pyroptosis in skin cells.

UR - https://www.scopus.com/pages/publications/85127765225

U2 - 10.1016/j.chom.2022.03.003

DO - 10.1016/j.chom.2022.03.003

M3 - Comment/debate

SN - 1931-3128

VL - 30

SP - 410

EP - 412

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 4

ER -

Streptococcus makes the cut: Gasdermin A-induced pyroptosis

Abstract

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