Striatal morphology and neurocognitive dysfunction in Huntington disease: The IMAGE-HD study

Fiona A. Wilkes; Z. Abaryan; Chris R.K. Ching; Boris A. Gutman; Sarah K. Madsen; Mark Walterfang; Dennis Velakoulis; Julie C. Stout; Phyllis Chua; Gary F. Egan; Paul M. Thompson; Jeffrey C.L. Looi; Nellie Georgiou-Karistianis

doi:10.1016/j.pscychresns.2019.07.003

Striatal morphology and neurocognitive dysfunction in Huntington disease: The IMAGE-HD study

Fiona A. Wilkes^*, Z. Abaryan, Chris R.K. Ching, Boris A. Gutman, Sarah K. Madsen, Mark Walterfang, Dennis Velakoulis, Julie C. Stout, Phyllis Chua, Gary F. Egan, Paul M. Thompson, Jeffrey C.L. Looi, Nellie Georgiou-Karistianis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We aimed to investigate the relationship between striatal morphology in Huntington disease (HD) and measures of motor and cognitive dysfunction. MRI scans, from the IMAGE-HD study, were obtained from 36 individuals with pre-symptomatic HD (pre-HD), 37 with early symptomatic HD (symp-HD), and 36 healthy matched controls. The neostriatum was manually segmented and a surface-based parametric mapping protocol derived two pointwise shape measures: thickness and surface dilation ratio. Significant shape differences were detected between all groups. Negative associations were detected between lower thickness and surface area shape measure and CAG repeats, disease burden score, and UHDRS total motor score. In symp-HD, UPSIT scores were correlated with higher thickness in left caudate tail and surface dilation ratio in left posterior putamen; Stroop scores were positively correlated with the thickness of left putamen head and body. Self-paced tapping (slow) was correlated with higher thickness and surface dilation ratio in the right caudate in symp-HD and with bilateral putamen in pre-HD. Self-paced tapping (fast) was correlated with higher surface dilation ratio in the right anterior putamen in symp-HD. Shape changes correlated with functional measures subserved by corticostriatal circuits, suggesting that the neostriatum is a potentially useful structural basis for characterisation of endophenotypes of HD.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Psychiatry Research - Neuroimaging
Volume	291
DOIs	https://doi.org/10.1016/j.pscychresns.2019.07.003
Publication status	Published - 30 Sept 2019

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Wilkes, F. A., Abaryan, Z., Ching, C. R. K., Gutman, B. A., Madsen, S. K., Walterfang, M., Velakoulis, D., Stout, J. C., Chua, P., Egan, G. F., Thompson, P. M., Looi, J. C. L., & Georgiou-Karistianis, N. (2019). Striatal morphology and neurocognitive dysfunction in Huntington disease: The IMAGE-HD study. Psychiatry Research - Neuroimaging, 291, 1-8. https://doi.org/10.1016/j.pscychresns.2019.07.003

@article{c597bef17b0c4dc2a67550615719eee3,

title = "Striatal morphology and neurocognitive dysfunction in Huntington disease: The IMAGE-HD study",

abstract = "We aimed to investigate the relationship between striatal morphology in Huntington disease (HD) and measures of motor and cognitive dysfunction. MRI scans, from the IMAGE-HD study, were obtained from 36 individuals with pre-symptomatic HD (pre-HD), 37 with early symptomatic HD (symp-HD), and 36 healthy matched controls. The neostriatum was manually segmented and a surface-based parametric mapping protocol derived two pointwise shape measures: thickness and surface dilation ratio. Significant shape differences were detected between all groups. Negative associations were detected between lower thickness and surface area shape measure and CAG repeats, disease burden score, and UHDRS total motor score. In symp-HD, UPSIT scores were correlated with higher thickness in left caudate tail and surface dilation ratio in left posterior putamen; Stroop scores were positively correlated with the thickness of left putamen head and body. Self-paced tapping (slow) was correlated with higher thickness and surface dilation ratio in the right caudate in symp-HD and with bilateral putamen in pre-HD. Self-paced tapping (fast) was correlated with higher surface dilation ratio in the right anterior putamen in symp-HD. Shape changes correlated with functional measures subserved by corticostriatal circuits, suggesting that the neostriatum is a potentially useful structural basis for characterisation of endophenotypes of HD.",

keywords = "Biomarker Huntington disease, Endophenotype, Neostriatum",

author = "Wilkes, {Fiona A.} and Z. Abaryan and Ching, {Chris R.K.} and Gutman, {Boris A.} and Madsen, {Sarah K.} and Mark Walterfang and Dennis Velakoulis and Stout, {Julie C.} and Phyllis Chua and Egan, {Gary F.} and Thompson, {Paul M.} and Looi, {Jeffrey C.L.} and Nellie Georgiou-Karistianis",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = sep,

day = "30",

doi = "10.1016/j.pscychresns.2019.07.003",

language = "English",

volume = "291",

pages = "1--8",

journal = "Psychiatry Research - Neuroimaging",

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Wilkes, FA, Abaryan, Z, Ching, CRK, Gutman, BA, Madsen, SK, Walterfang, M, Velakoulis, D, Stout, JC, Chua, P, Egan, GF, Thompson, PM, Looi, JCL & Georgiou-Karistianis, N 2019, 'Striatal morphology and neurocognitive dysfunction in Huntington disease: The IMAGE-HD study', Psychiatry Research - Neuroimaging, vol. 291, pp. 1-8. https://doi.org/10.1016/j.pscychresns.2019.07.003

TY - JOUR

T1 - Striatal morphology and neurocognitive dysfunction in Huntington disease

T2 - The IMAGE-HD study

AU - Wilkes, Fiona A.

AU - Abaryan, Z.

AU - Ching, Chris R.K.

AU - Gutman, Boris A.

AU - Madsen, Sarah K.

AU - Walterfang, Mark

AU - Velakoulis, Dennis

AU - Stout, Julie C.

AU - Chua, Phyllis

AU - Egan, Gary F.

AU - Thompson, Paul M.

AU - Looi, Jeffrey C.L.

AU - Georgiou-Karistianis, Nellie

PY - 2019/9/30

Y1 - 2019/9/30

N2 - We aimed to investigate the relationship between striatal morphology in Huntington disease (HD) and measures of motor and cognitive dysfunction. MRI scans, from the IMAGE-HD study, were obtained from 36 individuals with pre-symptomatic HD (pre-HD), 37 with early symptomatic HD (symp-HD), and 36 healthy matched controls. The neostriatum was manually segmented and a surface-based parametric mapping protocol derived two pointwise shape measures: thickness and surface dilation ratio. Significant shape differences were detected between all groups. Negative associations were detected between lower thickness and surface area shape measure and CAG repeats, disease burden score, and UHDRS total motor score. In symp-HD, UPSIT scores were correlated with higher thickness in left caudate tail and surface dilation ratio in left posterior putamen; Stroop scores were positively correlated with the thickness of left putamen head and body. Self-paced tapping (slow) was correlated with higher thickness and surface dilation ratio in the right caudate in symp-HD and with bilateral putamen in pre-HD. Self-paced tapping (fast) was correlated with higher surface dilation ratio in the right anterior putamen in symp-HD. Shape changes correlated with functional measures subserved by corticostriatal circuits, suggesting that the neostriatum is a potentially useful structural basis for characterisation of endophenotypes of HD.

AB - We aimed to investigate the relationship between striatal morphology in Huntington disease (HD) and measures of motor and cognitive dysfunction. MRI scans, from the IMAGE-HD study, were obtained from 36 individuals with pre-symptomatic HD (pre-HD), 37 with early symptomatic HD (symp-HD), and 36 healthy matched controls. The neostriatum was manually segmented and a surface-based parametric mapping protocol derived two pointwise shape measures: thickness and surface dilation ratio. Significant shape differences were detected between all groups. Negative associations were detected between lower thickness and surface area shape measure and CAG repeats, disease burden score, and UHDRS total motor score. In symp-HD, UPSIT scores were correlated with higher thickness in left caudate tail and surface dilation ratio in left posterior putamen; Stroop scores were positively correlated with the thickness of left putamen head and body. Self-paced tapping (slow) was correlated with higher thickness and surface dilation ratio in the right caudate in symp-HD and with bilateral putamen in pre-HD. Self-paced tapping (fast) was correlated with higher surface dilation ratio in the right anterior putamen in symp-HD. Shape changes correlated with functional measures subserved by corticostriatal circuits, suggesting that the neostriatum is a potentially useful structural basis for characterisation of endophenotypes of HD.

KW - Biomarker Huntington disease

KW - Endophenotype

KW - Neostriatum

UR - http://www.scopus.com/inward/record.url?scp=85069584753&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2019.07.003

DO - 10.1016/j.pscychresns.2019.07.003

M3 - Article

SN - 0925-4927

VL - 291

SP - 1

EP - 8

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

ER -

Striatal morphology and neurocognitive dysfunction in Huntington disease: The IMAGE-HD study

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