Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine

Diane E. Webster; Michelle L. Cooney; Zhongjun Huang; Damien R. Drew; Ian A. Ramshaw; Ian B. Dry; Richard A. Strugnell; Jenny L. Martin; Steve L. Wesselingh

doi:10.1128/JVI.76.15.7910-7912.2002

Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine

Diane E. Webster, Michelle L. Cooney, Zhongjun Huang, Damien R. Drew, Ian A. Ramshaw, Ian B. Dry, Richard A. Strugnell, Jenny L. Martin, Steve L. Wesselingh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.

Original language	English
Pages (from-to)	7910-7912
Number of pages	3
Journal	Journal of Virology
Volume	76
Issue number	15
DOIs	https://doi.org/10.1128/JVI.76.15.7910-7912.2002
Publication status	Published - 2002
Externally published	Yes

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10.1128/JVI.76.15.7910-7912.2002

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title = "Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine",

abstract = "Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.",

author = "Webster, {Diane E.} and Cooney, {Michelle L.} and Zhongjun Huang and Drew, {Damien R.} and Ramshaw, {Ian A.} and Dry, {Ian B.} and Strugnell, {Richard A.} and Martin, {Jenny L.} and Wesselingh, {Steve L.}",

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AU - Webster, Diane E.

AU - Cooney, Michelle L.

AU - Huang, Zhongjun

AU - Drew, Damien R.

AU - Ramshaw, Ian A.

AU - Dry, Ian B.

AU - Strugnell, Richard A.

AU - Martin, Jenny L.

AU - Wesselingh, Steve L.

PY - 2002

Y1 - 2002

N2 - Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.

AB - Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.

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U2 - 10.1128/JVI.76.15.7910-7912.2002

DO - 10.1128/JVI.76.15.7910-7912.2002

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ER -

Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine

Abstract

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