18F-florbetaben Ab imaging in mild cognitive impairment

Kevin Ong, Victor L. Villemagne, Alex Bahar-Fuchs, Fiona Lamb, Gaël Chételat, Parnesh Raniga, Rachel S. Mulligan, Olivier Salvado, Barbara Putz, Katrin Roth, Colin L. Masters, Cornelia B. Reininger, Christopher C. Rowe*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    48 Citations (Scopus)

    Abstract

    Introduction: 18F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Ab) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI). Methods: Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Aβ burden. Correlations were adjusted for age, gender and years of education. Results: High Aβ burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with Aβ burden. Conclusion: Higher Ab deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.

    Original languageEnglish
    Article number4
    JournalAlzheimer's Research and Therapy
    Volume5
    Issue number1
    DOIs
    Publication statusPublished - 16 Jan 2013

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