TY - JOUR
T1 - 18F-florbetaben Ab imaging in mild cognitive impairment
AU - Ong, Kevin
AU - Villemagne, Victor L.
AU - Bahar-Fuchs, Alex
AU - Lamb, Fiona
AU - Chételat, Gaël
AU - Raniga, Parnesh
AU - Mulligan, Rachel S.
AU - Salvado, Olivier
AU - Putz, Barbara
AU - Roth, Katrin
AU - Masters, Colin L.
AU - Reininger, Cornelia B.
AU - Rowe, Christopher C.
N1 - Publisher Copyright:
© 2013 Ong et al.; licensee BioMed Central Ltd.
PY - 2013/1/16
Y1 - 2013/1/16
N2 - Introduction: 18F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Ab) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI). Methods: Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Aβ burden. Correlations were adjusted for age, gender and years of education. Results: High Aβ burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with Aβ burden. Conclusion: Higher Ab deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.
AB - Introduction: 18F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Ab) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI). Methods: Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Aβ burden. Correlations were adjusted for age, gender and years of education. Results: High Aβ burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with Aβ burden. Conclusion: Higher Ab deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.
UR - http://www.scopus.com/inward/record.url?scp=84872173056&partnerID=8YFLogxK
U2 - 10.1186/alzrt158
DO - 10.1186/alzrt158
M3 - Article
SN - 1758-9193
VL - 5
JO - Alzheimer's Research and Therapy
JF - Alzheimer's Research and Therapy
IS - 1
M1 - 4
ER -