Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit [n] uril (n = 7, 8)

Hang Yin; Qiaoxian Huang; Wenwen Zhao; David Bardelang; Didier Siri; Xiuping Chen; Simon M.Y. Lee; Ruibing Wang

doi:10.1021/acs.joc.8b00543

Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit [n] uril (n = 7, 8)

Hang Yin, Qiaoxian Huang, Wenwen Zhao, David Bardelang, Didier Siri, Xiuping Chen, Simon M.Y. Lee, Ruibing Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

This is the first time that cucurbit[7]uril and cucurbit[8]uril have been demonstrated to serve as synthetic receptors for a halonium guest species, diphenyleneiodonium, modulating its bioactivities and alleviating its cardiotoxicity, which further expands the onium family of guest molecules for the cucurbit[n]uril family and provides new insights for halonium-cucurbit[n]uril host-guest chemistry and its potential applications in pharmaceutical chemistry.

Original language	English
Pages (from-to)	4882-4887
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	83
Issue number	8
DOIs	https://doi.org/10.1021/acs.joc.8b00543
Publication status	Published - 20 Apr 2018
Externally published	Yes

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10.1021/acs.joc.8b00543

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title = "Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit [n] uril (n = 7, 8)",

abstract = "This is the first time that cucurbit[7]uril and cucurbit[8]uril have been demonstrated to serve as synthetic receptors for a halonium guest species, diphenyleneiodonium, modulating its bioactivities and alleviating its cardiotoxicity, which further expands the onium family of guest molecules for the cucurbit[n]uril family and provides new insights for halonium-cucurbit[n]uril host-guest chemistry and its potential applications in pharmaceutical chemistry.",

author = "Hang Yin and Qiaoxian Huang and Wenwen Zhao and David Bardelang and Didier Siri and Xiuping Chen and Lee, {Simon M.Y.} and Ruibing Wang",

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AU - Yin, Hang

AU - Huang, Qiaoxian

AU - Zhao, Wenwen

AU - Bardelang, David

AU - Siri, Didier

AU - Chen, Xiuping

AU - Lee, Simon M.Y.

AU - Wang, Ruibing

PY - 2018/4/20

Y1 - 2018/4/20

N2 - This is the first time that cucurbit[7]uril and cucurbit[8]uril have been demonstrated to serve as synthetic receptors for a halonium guest species, diphenyleneiodonium, modulating its bioactivities and alleviating its cardiotoxicity, which further expands the onium family of guest molecules for the cucurbit[n]uril family and provides new insights for halonium-cucurbit[n]uril host-guest chemistry and its potential applications in pharmaceutical chemistry.

AB - This is the first time that cucurbit[7]uril and cucurbit[8]uril have been demonstrated to serve as synthetic receptors for a halonium guest species, diphenyleneiodonium, modulating its bioactivities and alleviating its cardiotoxicity, which further expands the onium family of guest molecules for the cucurbit[n]uril family and provides new insights for halonium-cucurbit[n]uril host-guest chemistry and its potential applications in pharmaceutical chemistry.

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JF - Journal of Organic Chemistry

IS - 8

ER -

Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit [n] uril (n = 7, 8)

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