TY - JOUR
T1 - Synthesis, characterization and cytotoxicity of the gold(III) complexes of 4,5-dihydropyrazole-1-carbothioamide derivatives
AU - Wang, Shuxiang
AU - Shao, Wenqing
AU - Li, Hongdong
AU - Liu, Cui
AU - Wang, Ke
AU - Zhang, Jinchao
PY - 2011/5
Y1 - 2011/5
N2 - Eight new gold(III) complexes (1-8) of 5-aryl-3-(pyridin-2-yl)-4,5- dihydropyrazole-1-carbothioamide have been synthesized and characterized by elemental analysis, molar conductivity, IR, UV, 1H NMR, 13C NMR, MS, and thermal analysis techniques. The cytotoxicity was tested by MTT assay. The results indicate that the complexes 1-8 exert cytotoxic effects against HeLa and A549 cell lines. Moreover, the complexes 1, 4, 5, 7 and 8 have higher cytotoxicity than cisplatin against HeLa cell line. It suggests that the substituent groups on benzene have important effect on cytotoxicity.
AB - Eight new gold(III) complexes (1-8) of 5-aryl-3-(pyridin-2-yl)-4,5- dihydropyrazole-1-carbothioamide have been synthesized and characterized by elemental analysis, molar conductivity, IR, UV, 1H NMR, 13C NMR, MS, and thermal analysis techniques. The cytotoxicity was tested by MTT assay. The results indicate that the complexes 1-8 exert cytotoxic effects against HeLa and A549 cell lines. Moreover, the complexes 1, 4, 5, 7 and 8 have higher cytotoxicity than cisplatin against HeLa cell line. It suggests that the substituent groups on benzene have important effect on cytotoxicity.
KW - Cytotoxicity
KW - Dihydropyrazole derivative
KW - Gold(III) complex
UR - http://www.scopus.com/inward/record.url?scp=79953190384&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2011.02.031
DO - 10.1016/j.ejmech.2011.02.031
M3 - Article
SN - 0223-5234
VL - 46
SP - 1914
EP - 1918
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 5
ER -