Synthesis of gold-coated magnetic conglomerate nanoparticles with a fast magnetic response for bio-sensing

Milad Mehdipour; Lucy Gloag; Danielle T. Bennett; Sharmin Hoque; Raheleh Pardehkhorram; Padmavathy Bakthavathsalam; Vinicius R. Goncales; Richard D. Tilley; J. Justin Gooding

doi:10.1039/d0tc04702c

Synthesis of gold-coated magnetic conglomerate nanoparticles with a fast magnetic response for bio-sensing

Milad Mehdipour, Lucy Gloag, Danielle T. Bennett, Sharmin Hoque, Raheleh Pardehkhorram, Padmavathy Bakthavathsalam, Vinicius R. Goncales, Richard D. Tilley, J. Justin Gooding

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The versatile qualities of gold coated magnetic nanoparticles for both optical and electrochemical detection, as well as the separation of analytes, make them an excellent choice for ultrasensitive biosensing applications. The challenge with such nanoparticles however is that strongly magnetic nanoparticles that reach the magnet rapidly are prone to aggregation, whilst superparamagnetic nanoparticles that are stable against aggregation reach the magnet slowly. Here, we report a conglomerate nanostructure consisting of superparamagnetic nanoparticles coated with gold that provides a rapid magnetic response while exhibiting colloidal stability in solution. The performance of these gold coated magnetic nanoparticles for both bio-separation and biosensing was demonstrated for application in biosensors, dispersible electrodes for detecting microRNA and surface-enhanced Raman scattering.

Original language	English
Pages (from-to)	1034-1043
Number of pages	10
Journal	Journal of Materials Chemistry C
Volume	9
Issue number	3
Early online date	8 Dec 2020
DOIs	https://doi.org/10.1039/d0tc04702c
Publication status	Published - 21 Jan 2021
Externally published	Yes

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abstract = "The versatile qualities of gold coated magnetic nanoparticles for both optical and electrochemical detection, as well as the separation of analytes, make them an excellent choice for ultrasensitive biosensing applications. The challenge with such nanoparticles however is that strongly magnetic nanoparticles that reach the magnet rapidly are prone to aggregation, whilst superparamagnetic nanoparticles that are stable against aggregation reach the magnet slowly. Here, we report a conglomerate nanostructure consisting of superparamagnetic nanoparticles coated with gold that provides a rapid magnetic response while exhibiting colloidal stability in solution. The performance of these gold coated magnetic nanoparticles for both bio-separation and biosensing was demonstrated for application in biosensors, dispersible electrodes for detecting microRNA and surface-enhanced Raman scattering.",

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AU - Gloag, Lucy

AU - Bennett, Danielle T.

AU - Hoque, Sharmin

AU - Pardehkhorram, Raheleh

AU - Bakthavathsalam, Padmavathy

AU - Goncales, Vinicius R.

AU - Tilley, Richard D.

AU - Gooding, J. Justin

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KW - Metal nanoparticles

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KW - Functionalization

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Synthesis of gold-coated magnetic conglomerate nanoparticles with a fast magnetic response for bio-sensing

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