Synthesis of indoles via palladium[0]-mediated ullmann cross-coupling of o-halonitroarenes with α-halo-enones or -enals

Martin G. Banwell*, Brian D. Kelly, Okanya J. Kokas, David W. Lupton

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    103 Citations (Scopus)

    Abstract

    (Matrix presented) Palladium[0]-mediated Ullmann cross-coupling of o-halonitrobenzene (1) and various related nitroarenes with a range of α-halo-enones (e.g., 2) or -enals readily affords the expected α-arylenones, e.g., 3, or -enals, which are converted into the corresponding indoles, e.g., 4, on reaction with dihydrogen in the presence of Pd on C.

    Original languageEnglish
    Pages (from-to)2497-2500
    Number of pages4
    JournalOrganic Letters
    Volume5
    Issue number14
    DOIs
    Publication statusPublished - 10 Jul 2003

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