Abstract
An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the TN and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam3CysSer were synthesised in high yields using a fragment-based condensation strategy.
Original language | English |
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Pages (from-to) | 6249-6251 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 46 |
Issue number | 34 |
DOIs | |
Publication status | Published - 14 Sept 2010 |
Externally published | Yes |