Synthesis of MUC1-lipopeptide chimeras

Brendan L. Wilkinson; Lara R. Malins; Candy K.Y. Chun; Richard J. Payne

doi:10.1039/c0cc01360a

Synthesis of MUC1-lipopeptide chimeras

Brendan L. Wilkinson, Lara R. Malins, Candy K.Y. Chun, Richard J. Payne

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T_N and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam₃CysSer were synthesised in high yields using a fragment-based condensation strategy.

Original language	English
Pages (from-to)	6249-6251
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	34
DOIs	https://doi.org/10.1039/c0cc01360a
Publication status	Published - 14 Sept 2010
Externally published	Yes

Access to Document

10.1039/c0cc01360a

Cite this

@article{3deafc8682d9406d96f75b625c3d33ec,

title = "Synthesis of MUC1-lipopeptide chimeras",

abstract = "An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the TN and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam3CysSer were synthesised in high yields using a fragment-based condensation strategy.",

author = "Wilkinson, \{Brendan L.\} and Malins, \{Lara R.\} and Chun, \{Candy K.Y.\} and Payne, \{Richard J.\}",

year = "2010",

month = sep,

day = "14",

doi = "10.1039/c0cc01360a",

language = "English",

volume = "46",

pages = "6249--6251",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "34",

}

TY - JOUR

T1 - Synthesis of MUC1-lipopeptide chimeras

AU - Wilkinson, Brendan L.

AU - Malins, Lara R.

AU - Chun, Candy K.Y.

AU - Payne, Richard J.

PY - 2010/9/14

Y1 - 2010/9/14

N2 - An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the TN and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam3CysSer were synthesised in high yields using a fragment-based condensation strategy.

AB - An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the TN and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam3CysSer were synthesised in high yields using a fragment-based condensation strategy.

UR - https://www.scopus.com/pages/publications/77955792337

U2 - 10.1039/c0cc01360a

DO - 10.1039/c0cc01360a

M3 - Article

SN - 1359-7345

VL - 46

SP - 6249

EP - 6251

JO - Chemical Communications

JF - Chemical Communications

IS - 34

ER -

Synthesis of MUC1-lipopeptide chimeras

Abstract

Access to Document

Other files and links

Fingerprint

Cite this