Synthesis of NTA3-DTDA - A chelator-lipid that promotes stable binding of his-tagged proteins to membranes

Joseph G. Altin; Martin G. Banwell; Phillip A. Coghlan; Christopher J. Easton; Michael R. Nairn; Daniel A. Offermann

doi:10.1071/CH06112

Synthesis of NTA₃-DTDA - A chelator-lipid that promotes stable binding of his-tagged proteins to membranes

Joseph G. Altin, Martin G. Banwell^*, Phillip A. Coghlan, Christopher J. Easton, Michael R. Nairn, Daniel A. Offermann

^*Corresponding author for this work

Research School of Chemistry

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19 Citations (Scopus)

Abstract

A six-step reaction sequence is described for the preparation of compound 1 (NTA₃-DTDA), a membrane-penetrating and potent chelator that can be incorporated into liposomes and plasma membrane vesicles containing antigens and thus allowing targeted delivery of such assemblies to a variety of cells for the purposes of eliciting anti-tumour responses. Full spectroscopic characterization of this dendritic-type compound as well as certain of its precursors is reported.

Original language	English
Pages (from-to)	302-306
Number of pages	5
Journal	Australian Journal of Chemistry
Volume	59
Issue number	5
DOIs	https://doi.org/10.1071/CH06112
Publication status	Published - 2006

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10.1071/CH06112

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abstract = "A six-step reaction sequence is described for the preparation of compound 1 (NTA3-DTDA), a membrane-penetrating and potent chelator that can be incorporated into liposomes and plasma membrane vesicles containing antigens and thus allowing targeted delivery of such assemblies to a variety of cells for the purposes of eliciting anti-tumour responses. Full spectroscopic characterization of this dendritic-type compound as well as certain of its precursors is reported.",

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AU - Easton, Christopher J.

AU - Nairn, Michael R.

AU - Offermann, Daniel A.

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AB - A six-step reaction sequence is described for the preparation of compound 1 (NTA3-DTDA), a membrane-penetrating and potent chelator that can be incorporated into liposomes and plasma membrane vesicles containing antigens and thus allowing targeted delivery of such assemblies to a variety of cells for the purposes of eliciting anti-tumour responses. Full spectroscopic characterization of this dendritic-type compound as well as certain of its precursors is reported.

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DO - 10.1071/CH06112

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Synthesis of NTA₃-DTDA - A chelator-lipid that promotes stable binding of his-tagged proteins to membranes

Abstract

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