Synthesis of NTA3-DTDA - A chelator-lipid that promotes stable binding of his-tagged proteins to membranes

Joseph G. Altin; Martin G. Banwell; Phillip A. Coghlan; Christopher J. Easton; Michael R. Nairn; Daniel A. Offermann

doi:10.1071/CH06112

Synthesis of NTA₃-DTDA - A chelator-lipid that promotes stable binding of his-tagged proteins to membranes

Joseph G. Altin
, Martin G. Banwell^*
, Phillip A. Coghlan
, Christopher J. Easton
, Michael R. Nairn
, Daniel A. Offermann

^*Corresponding author for this work

Research School of Chemistry

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A six-step reaction sequence is described for the preparation of compound 1 (NTA₃-DTDA), a membrane-penetrating and potent chelator that can be incorporated into liposomes and plasma membrane vesicles containing antigens and thus allowing targeted delivery of such assemblies to a variety of cells for the purposes of eliciting anti-tumour responses. Full spectroscopic characterization of this dendritic-type compound as well as certain of its precursors is reported.

Original language	English
Pages (from-to)	302-306
Number of pages	5
Journal	Australian Journal of Chemistry
Volume	59
Issue number	5
DOIs	https://doi.org/10.1071/CH06112
Publication status	Published - 2006

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10.1071/CH06112

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title = "Synthesis of NTA3-DTDA - A chelator-lipid that promotes stable binding of his-tagged proteins to membranes",

abstract = "A six-step reaction sequence is described for the preparation of compound 1 (NTA3-DTDA), a membrane-penetrating and potent chelator that can be incorporated into liposomes and plasma membrane vesicles containing antigens and thus allowing targeted delivery of such assemblies to a variety of cells for the purposes of eliciting anti-tumour responses. Full spectroscopic characterization of this dendritic-type compound as well as certain of its precursors is reported.",

author = "Altin, \{Joseph G.\} and Banwell, \{Martin G.\} and Coghlan, \{Phillip A.\} and Easton, \{Christopher J.\} and Nairn, \{Michael R.\} and Offermann, \{Daniel A.\}",

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pages = "302--306",

journal = "Australian Journal of Chemistry",

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AU - Altin, Joseph G.

AU - Banwell, Martin G.

AU - Coghlan, Phillip A.

AU - Easton, Christopher J.

AU - Nairn, Michael R.

AU - Offermann, Daniel A.

PY - 2006

Y1 - 2006

N2 - A six-step reaction sequence is described for the preparation of compound 1 (NTA3-DTDA), a membrane-penetrating and potent chelator that can be incorporated into liposomes and plasma membrane vesicles containing antigens and thus allowing targeted delivery of such assemblies to a variety of cells for the purposes of eliciting anti-tumour responses. Full spectroscopic characterization of this dendritic-type compound as well as certain of its precursors is reported.

AB - A six-step reaction sequence is described for the preparation of compound 1 (NTA3-DTDA), a membrane-penetrating and potent chelator that can be incorporated into liposomes and plasma membrane vesicles containing antigens and thus allowing targeted delivery of such assemblies to a variety of cells for the purposes of eliciting anti-tumour responses. Full spectroscopic characterization of this dendritic-type compound as well as certain of its precursors is reported.

UR - https://www.scopus.com/pages/publications/33745025037

U2 - 10.1071/CH06112

DO - 10.1071/CH06112

M3 - Article

SN - 0004-9425

VL - 59

SP - 302

EP - 306

JO - Australian Journal of Chemistry

JF - Australian Journal of Chemistry

IS - 5

ER -

Synthesis of NTA₃-DTDA - A chelator-lipid that promotes stable binding of his-tagged proteins to membranes

Abstract

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