Synthesis of spiroisoxazolines through cycloadditions of nitrile oxides with 3-methylenequinuclidine

Connie K.Y. Lee; Christopher J. Easton; G. Paul Savage; Gregory W. Simpson

Synthesis of spiroisoxazolines through cycloadditions of nitrile oxides with 3-methylenequinuclidine

Connie K.Y. Lee, Christopher J. Easton^*, G. Paul Savage, Gregory W. Simpson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Four spiroisoxazolines have been prepared, by cycloaddition of aceto-, pivalo-, benzo- and mesito-nitrile oxide with 3-methylenequinuclidine. The reactions were completely regioselective, within the limits of detection. None of the isoxazolines showed significant inhibition of acetylcholinesterase.

Original language	English
Pages (from-to)	175-183
Number of pages	9
Journal	Arkivoc
Volume	2006
Issue number	3
Publication status	Published - 10 Sept 2005

Cite this

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title = "Synthesis of spiroisoxazolines through cycloadditions of nitrile oxides with 3-methylenequinuclidine",

abstract = "Four spiroisoxazolines have been prepared, by cycloaddition of aceto-, pivalo-, benzo- and mesito-nitrile oxide with 3-methylenequinuclidine. The reactions were completely regioselective, within the limits of detection. None of the isoxazolines showed significant inhibition of acetylcholinesterase.",

keywords = "Acetylcholinesterase, Alzheimer's disease, Cycloadditions, Isoxazolines, Nitrile oxides, Quinuclidine",

author = "Lee, {Connie K.Y.} and Easton, {Christopher J.} and Savage, {G. Paul} and Simpson, {Gregory W.}",

year = "2005",

month = sep,

day = "10",

language = "English",

volume = "2006",

pages = "175--183",

journal = "Arkivoc",

issn = "1551-7004",

publisher = "Arkat USA",

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T1 - Synthesis of spiroisoxazolines through cycloadditions of nitrile oxides with 3-methylenequinuclidine

AU - Lee, Connie K.Y.

AU - Easton, Christopher J.

AU - Savage, G. Paul

AU - Simpson, Gregory W.

PY - 2005/9/10

Y1 - 2005/9/10

N2 - Four spiroisoxazolines have been prepared, by cycloaddition of aceto-, pivalo-, benzo- and mesito-nitrile oxide with 3-methylenequinuclidine. The reactions were completely regioselective, within the limits of detection. None of the isoxazolines showed significant inhibition of acetylcholinesterase.

AB - Four spiroisoxazolines have been prepared, by cycloaddition of aceto-, pivalo-, benzo- and mesito-nitrile oxide with 3-methylenequinuclidine. The reactions were completely regioselective, within the limits of detection. None of the isoxazolines showed significant inhibition of acetylcholinesterase.

KW - Acetylcholinesterase

KW - Alzheimer's disease

KW - Cycloadditions

KW - Isoxazolines

KW - Nitrile oxides

KW - Quinuclidine

UR - http://www.scopus.com/inward/record.url?scp=27744436125&partnerID=8YFLogxK

M3 - Article

SN - 1551-7004

VL - 2006

SP - 175

EP - 183

JO - Arkivoc

JF - Arkivoc

IS - 3

ER -

Synthesis of spiroisoxazolines through cycloadditions of nitrile oxides with 3-methylenequinuclidine

Abstract

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