Synthesis, structure characterization, DNA binding, and cleavage properties of mononuclear and tetranuclear cluster of copper(II) complexes

Rasoul Vafazadeh*, Naime Hasanzade, Mohammad Mehdi Heidari, Anthony C. Willis

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Two copper(II) complexes, cluster 1, and mononuclear 2, have been synthesized by reacting acetylacetone and benzohydrazide (1:1 ratio for 1 and 1:2 ratio for 2) with CuCl2 in a methanol solution. In 2, which is a new complex, the ligand acts as a tetradentate which binds the metal ion via two amide-O atoms and two imine-N atoms providing an N2O2 squa-re-planar around the copper(II) ion. The absorption spectra data evidence strongly suggested that the two copper(II) compounds could interact with CT-DNA (intrinsic binding constant, Kb = 0.45 × 104 M-1 for 1 and Kb = 2.39 × 104 M-1 for 2). The super coiled plasmid pBR322 DNA cleavage ability was studied with 1 and 2 in the presence and absence of H2O2 as an oxidant. In both the absence and the presence of an oxidizing agent, complex 2 exhibited no nuclease activity. However, even in the absence of an oxidant, complex 1 exhibited significant DNA cleavage activity.

    Original languageEnglish
    Pages (from-to)122-129
    Number of pages8
    JournalActa Chimica Slovenica
    Volume62
    Issue number1
    DOIs
    Publication statusPublished - 2015

    Fingerprint

    Dive into the research topics of 'Synthesis, structure characterization, DNA binding, and cleavage properties of mononuclear and tetranuclear cluster of copper(II) complexes'. Together they form a unique fingerprint.

    Cite this