Abstract
The synthesis of the structure, 1, assigned to the anti-inflammatory natural product myrsinoic acid F is reported together with a means for preparing its Z-isomer 21. While neither of these compounds corresponds to the natural product, both of them are anti-inflammatory agents (as determined using a mouse ear edema assay) with congener 1 being notably more potent than the widely prescribed NSAID indometacin.
Original language | English |
---|---|
Pages (from-to) | 3984-3987 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 20 |
Issue number | 13 |
DOIs | |
Publication status | Published - 6 Jul 2018 |