Synthetic Studies on the Natural Product Myrsinoic Acid F Reveal Biologically Active Analogues

Jiri Mikusek, Jeremy Nugent, Jas S. Ward, Brett D. Schwartz, Alison D. Findlay, Jonathan S. Foot, Martin G. Banwell*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    The synthesis of the structure, 1, assigned to the anti-inflammatory natural product myrsinoic acid F is reported together with a means for preparing its Z-isomer 21. While neither of these compounds corresponds to the natural product, both of them are anti-inflammatory agents (as determined using a mouse ear edema assay) with congener 1 being notably more potent than the widely prescribed NSAID indometacin.

    Original languageEnglish
    Pages (from-to)3984-3987
    Number of pages4
    JournalOrganic Letters
    Volume20
    Issue number13
    DOIs
    Publication statusPublished - 6 Jul 2018

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