TY - JOUR
T1 - Systems medicine disease
T2 - Disease classification and scalability beyond networks and boundary conditions
AU - Berlin, Richard
AU - Gruen, Russell
AU - Best, James
N1 - Publisher Copyright:
© 2018 Berlin, Gruen and Best.
PY - 2018/8/7
Y1 - 2018/8/7
N2 - In order to accommodate the forthcoming wealth of health and disease related information, from genome to body sensors to population and the environment, the approach to disease description and definition demands re-examination. Traditional classification methods remain trapped by history; to provide the descriptive features that are required for a comprehensive description of disease, systems science, which realizes dynamic processes, adaptive response, and asynchronous communication channels, must be applied (Wolkenhauer et al., 2013). When Disease is viewed beyond the thresholds of lines and threshold boundaries, disease definition is not only the result of reductionist, mechanistic categories which reluctantly face re-composition. Disease is process and synergy as the characteristics of Systems Biology and Systems Medicine are included. To capture the wealth of information and contribute meaningfully to medical practice and biology research, Disease classification goes beyond a single spatial biologic level or static time assignment to include the interface of Disease process and organism response (Bechtel, 2017a; Green et al., 2017).
AB - In order to accommodate the forthcoming wealth of health and disease related information, from genome to body sensors to population and the environment, the approach to disease description and definition demands re-examination. Traditional classification methods remain trapped by history; to provide the descriptive features that are required for a comprehensive description of disease, systems science, which realizes dynamic processes, adaptive response, and asynchronous communication channels, must be applied (Wolkenhauer et al., 2013). When Disease is viewed beyond the thresholds of lines and threshold boundaries, disease definition is not only the result of reductionist, mechanistic categories which reluctantly face re-composition. Disease is process and synergy as the characteristics of Systems Biology and Systems Medicine are included. To capture the wealth of information and contribute meaningfully to medical practice and biology research, Disease classification goes beyond a single spatial biologic level or static time assignment to include the interface of Disease process and organism response (Bechtel, 2017a; Green et al., 2017).
KW - Boundary conditions
KW - Disease
KW - Networks
KW - Scalability
KW - Systems medicine
UR - http://www.scopus.com/inward/record.url?scp=85052898670&partnerID=8YFLogxK
U2 - 10.3389/fbioe.2018.00112
DO - 10.3389/fbioe.2018.00112
M3 - Article
SN - 2296-4185
VL - 6
JO - Frontiers in Bioengineering and Biotechnology
JF - Frontiers in Bioengineering and Biotechnology
IS - AUG
M1 - 112
ER -