Ten millennia of hepatitis B virus evolution

Arthur Kocher; Luka Papac; Rodrigo Barquera; Felix M. Key; Maria A. Spyrou; Ron Hübler; Adam B. Rohrlach2; Franziska Aron; Raphaela Stahl; Antje Wissgott; Florian Van Bömme; Maria Pfefferkorn; Mittnik Alissa; Vanessa Villalba-Mouco; Gunnar U. Neumann; Maït Rivollat; Marieke S. Van De Loosdrecht; Kerttu Majander; Rezeda I. Tukhbatova; Lyazzat Musralina; Ayshin Ghalichi; Sandra Penske; Susanna Sabin; Megan Michel; Joscha Gretzinger; Elizabeth A. Nelson; Tiago Ferraz; Kathrin Nägele; Cody Parker; Marcel Keller; Evelyn K. Guevara; Michal Feldman; Stefanie Eisenmann; Eirini Skourtanioti; Karen Giffin; Guido Alberto Gnecchi-Ruscone; Susanne Friederich; Vittoria Schimmenti; Valery Khartanovich; Marina K. Karapetian; Mikhail S. Chaplygin; Vladimir V. Kufterin; Aleksandr A. Khokhlov; Andrey A. Chizhevsky; Dmitry A. Stashenkov; Anna F. Kochkina; Cristina Tejedor-Rodríguez; Íñigo García Martínez De Lagrán; Héctor Arcusa-Magallón; Rafael Garrido-Pena; José Ignacio Royo-Guillén; Jan Nováček; Stéphane Rottier; Sacha Kacki; Sylvie Saintot; Elena Kaverzneva; Andrej B. Belinskiy; Petr Velemínský; Petr Limburský; Michal Kostka; Louise Loe; Elizabeth Popescu; Rachel Clarke; Alice Lyons; Richard Mortimer; Antti Sajantila; Yadira Chinique De Armas; Silvia Teresita Hernandez Godoy; Diana I. Hernández-Zaragoza; Jessica Pearson; Didier Binder; Philippe Lefranc; Anatoly R. Kantorovich; Vladimir E. Maslov; Luca Lai; Magdalena Zoledziewska; Jessica F. Beckett; Michaela Langová; Alžběta Danielisová; Tara Ingman; Gabriel García Atiénzar; Maria Paz De Miguel Ibáñez; Alejandro Romero; Alessandra Sperduti; Sophie Beckett; Susannah J. Salter; Emma D. Zilivinskaya; Dmitry V. Vasil'ev; Kristin Von Heyking; Richard L. Burger; Lucy C. Salazar; Luc Amkreutz; Masnav Navruzbekov; Eva Rosenstock; Carmen Alonso-Fernández; Vladimir Slavchev; Alexey A. Kalmykov; Biaslan Ch Atabiev; Elena Batieva; Micaela Alvarez Calmet; Bastien Llamas; Michael Schultz; Raiko Krauß; Javier Jiménez-Echevarría; Michael Francken; Svetlana Shnaider; Peter De Knijff; Eveline Altena; Katrien Van De Vijver; Lars Fehren-Schmitz; Tiffiny A. Tung; Sandra Lösch; Maria Dobrovolskaya; Nikolaj Makarov; Chris Read; Melanie Van Twest; Claudia Sagona; Peter C. Ramsl; Murat Akar; K. Aslihan Yener; Eduardo Carmona Ballestero; Francesco Cucca; Vittorio Mazzarello; Pilar Utrilla; Kurt Rademaker; Eva Fernández-Domínguez; Douglas Baird; Patrick Semal; Lourdes Márquez-Morfín; Mirjana Roksandic; Hubert Steiner; Domingo Carlos Salazar-García; Natalia Shishlina; Yilmaz Selim Erdal; Fredrik Hallgren; Yavor Boyadzhiev; Kamen Boyadzhiev; Mario Küßner; Duncan Sayer; Päivi Onkamo; Robin Skeates; Manuel Rojo-Guerra; Alexandra Buzhilova; Elmira Khussainova; Leyla B. Djansugurova; Arman Z. Beisenov; Zainolla Samashev; Ken Massy; Marcello Mannino; Vyacheslav Moiseyev; Kristiina Mannermaa; Oleg Balanovsky; Marie France Deguilloux; Sabine Reinhold; Svend Hansen; Egor P. Kitov; Miroslav Dobeš; Michal Ernée; Harald Meller; Alt W. Kurt; Kay Prüfer; Christina Warinner; Stephan Schiffels; Philipp W. Stockhammer; Kirsten Bos; Cosimo Posth; Alexander Herbig; Wolfgang Haak; Johannes Krause2; Johannes Krause2; Arthur Kocher

doi:10.1126/science.abi5658

Ten millennia of hepatitis B virus evolution

Arthur Kocher, Luka Papac, Rodrigo Barquera, Felix M. Key, Maria A. Spyrou, Ron Hübler, Adam B. Rohrlach2, Franziska Aron, Raphaela Stahl, Antje Wissgott, Florian Van Bömme, Maria Pfefferkorn, Mittnik Alissa, Vanessa Villalba-Mouco, Gunnar U. Neumann, Maït Rivollat, Marieke S. Van De Loosdrecht, Kerttu Majander, Rezeda I. Tukhbatova, Lyazzat MusralinaAyshin Ghalichi, Sandra Penske, Susanna Sabin, Megan Michel, Joscha Gretzinger, Elizabeth A. Nelson, Tiago Ferraz, Kathrin Nägele, Cody Parker, Marcel Keller, Evelyn K. Guevara, Michal Feldman, Stefanie Eisenmann, Eirini Skourtanioti, Karen Giffin, Guido Alberto Gnecchi-Ruscone, Susanne Friederich, Vittoria Schimmenti, Valery Khartanovich, Marina K. Karapetian, Mikhail S. Chaplygin, Vladimir V. Kufterin, Aleksandr A. Khokhlov, Andrey A. Chizhevsky, Dmitry A. Stashenkov, Anna F. Kochkina, Cristina Tejedor-Rodríguez, Íñigo García Martínez De Lagrán, Héctor Arcusa-Magallón, Rafael Garrido-Pena, José Ignacio Royo-Guillén, Jan Nováček, Stéphane Rottier, Sacha Kacki, Sylvie Saintot, Elena Kaverzneva, Andrej B. Belinskiy, Petr Velemínský, Petr Limburský, Michal Kostka, Louise Loe, Elizabeth Popescu, Rachel Clarke, Alice Lyons, Richard Mortimer, Antti Sajantila, Yadira Chinique De Armas, Silvia Teresita Hernandez Godoy, Diana I. Hernández-Zaragoza, Jessica Pearson, Didier Binder, Philippe Lefranc, Anatoly R. Kantorovich, Vladimir E. Maslov, Luca Lai, Magdalena Zoledziewska, Jessica F. Beckett, Michaela Langová, Alžběta Danielisová, Tara Ingman, Gabriel García Atiénzar, Maria Paz De Miguel Ibáñez, Alejandro Romero, Alessandra Sperduti, Sophie Beckett, Susannah J. Salter, Emma D. Zilivinskaya, Dmitry V. Vasil'ev, Kristin Von Heyking, Richard L. Burger, Lucy C. Salazar, Luc Amkreutz, Masnav Navruzbekov, Eva Rosenstock, Carmen Alonso-Fernández, Vladimir Slavchev, Alexey A. Kalmykov, Biaslan Ch Atabiev, Elena Batieva, Micaela Alvarez Calmet, Bastien Llamas, Michael Schultz, Raiko Krauß, Javier Jiménez-Echevarría, Michael Francken, Svetlana Shnaider, Peter De Knijff, Eveline Altena, Katrien Van De Vijver, Lars Fehren-Schmitz, Tiffiny A. Tung, Sandra Lösch, Maria Dobrovolskaya, Nikolaj Makarov, Chris Read, Melanie Van Twest, Claudia Sagona, Peter C. Ramsl, Murat Akar, K. Aslihan Yener, Eduardo Carmona Ballestero, Francesco Cucca, Vittorio Mazzarello, Pilar Utrilla, Kurt Rademaker, Eva Fernández-Domínguez, Douglas Baird, Patrick Semal, Lourdes Márquez-Morfín, Mirjana Roksandic, Hubert Steiner, Domingo Carlos Salazar-García, Natalia Shishlina, Yilmaz Selim Erdal, Fredrik Hallgren, Yavor Boyadzhiev, Kamen Boyadzhiev, Mario Küßner, Duncan Sayer, Päivi Onkamo, Robin Skeates, Manuel Rojo-Guerra, Alexandra Buzhilova, Elmira Khussainova, Leyla B. Djansugurova, Arman Z. Beisenov, Zainolla Samashev, Ken Massy, Marcello Mannino, Vyacheslav Moiseyev, Kristiina Mannermaa, Oleg Balanovsky, Marie France Deguilloux, Sabine Reinhold, Svend Hansen, Egor P. Kitov, Miroslav Dobeš, Michal Ernée, Harald Meller, Alt W. Kurt, Kay Prüfer, Christina Warinner, Stephan Schiffels, Philipp W. Stockhammer, Kirsten Bos, Cosimo Posth, Alexander Herbig, Wolfgang Haak, Johannes Krause2, Johannes Krause2, Arthur Kocher

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.

Original language	English
Journal	Science
Volume	374
Issue number	6564
DOIs	https://doi.org/10.1126/science.abi5658
Publication status	Published - 8 Oct 2021

Access to Document

10.1126/science.abi5658

Cite this

Kocher, A., Papac, L., Barquera, R., Key, F. M., Spyrou, M. A., Hübler, R., Rohrlach2, A. B., Aron, F., Stahl, R., Wissgott, A., Van Bömme, F., Pfefferkorn, M., Alissa, M., Villalba-Mouco, V., Neumann, G. U., Rivollat, M., Van De Loosdrecht, M. S., Majander, K., Tukhbatova, R. I., ... Kocher, A. (2021). Ten millennia of hepatitis B virus evolution. Science, 374(6564). https://doi.org/10.1126/science.abi5658

@article{d2e3a115d6054ac5b5a87e30e7927dc3,

title = "Ten millennia of hepatitis B virus evolution",

abstract = "Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.",

author = "Arthur Kocher and Luka Papac and Rodrigo Barquera and Key, {Felix M.} and Spyrou, {Maria A.} and Ron H{\"u}bler and Rohrlach2, {Adam B.} and Franziska Aron and Raphaela Stahl and Antje Wissgott and {Van B{\"o}mme}, Florian and Maria Pfefferkorn and Mittnik Alissa and Vanessa Villalba-Mouco and Neumann, {Gunnar U.} and Ma{\"i}t Rivollat and {Van De Loosdrecht}, {Marieke S.} and Kerttu Majander and Tukhbatova, {Rezeda I.} and Lyazzat Musralina and Ayshin Ghalichi and Sandra Penske and Susanna Sabin and Megan Michel and Joscha Gretzinger and Nelson, {Elizabeth A.} and Tiago Ferraz and Kathrin N{\"a}gele and Cody Parker and Marcel Keller and Guevara, {Evelyn K.} and Michal Feldman and Stefanie Eisenmann and Eirini Skourtanioti and Karen Giffin and Gnecchi-Ruscone, {Guido Alberto} and Susanne Friederich and Vittoria Schimmenti and Valery Khartanovich and Karapetian, {Marina K.} and Chaplygin, {Mikhail S.} and Kufterin, {Vladimir V.} and Khokhlov, {Aleksandr A.} and Chizhevsky, {Andrey A.} and Stashenkov, {Dmitry A.} and Kochkina, {Anna F.} and Cristina Tejedor-Rodr{\'i}guez and {De Lagr{\'a}n}, {{\'I}{\~n}igo Garc{\'i}a Mart{\'i}nez} and H{\'e}ctor Arcusa-Magall{\'o}n and Rafael Garrido-Pena and Royo-Guill{\'e}n, {Jos{\'e} Ignacio} and Jan Nov{\'a}{\v c}ek and St{\'e}phane Rottier and Sacha Kacki and Sylvie Saintot and Elena Kaverzneva and Belinskiy, {Andrej B.} and Petr Velem{\'i}nsk{\'y} and Petr Limbursk{\'y} and Michal Kostka and Louise Loe and Elizabeth Popescu and Rachel Clarke and Alice Lyons and Richard Mortimer and Antti Sajantila and Armas, {Yadira Chinique De} and Godoy, {Silvia Teresita Hernandez} and Hern{\'a}ndez-Zaragoza, {Diana I.} and Jessica Pearson and Didier Binder and Philippe Lefranc and Kantorovich, {Anatoly R.} and Maslov, {Vladimir E.} and Luca Lai and Magdalena Zoledziewska and Beckett, {Jessica F.} and Michaela Langov{\'a} and Al{\v z}b{\v e}ta Danielisov{\'a} and Tara Ingman and Ati{\'e}nzar, {Gabriel Garc{\'i}a} and Ib{\'a}{\~n}ez, {Maria Paz De Miguel} and Alejandro Romero and Alessandra Sperduti and Sophie Beckett and Salter, {Susannah J.} and Zilivinskaya, {Emma D.} and Vasil'ev, {Dmitry V.} and Heyking, {Kristin Von} and Burger, {Richard L.} and Salazar, {Lucy C.} and Luc Amkreutz and Masnav Navruzbekov and Eva Rosenstock and Carmen Alonso-Fern{\'a}ndez and Vladimir Slavchev and Kalmykov, {Alexey A.} and Atabiev, {Biaslan Ch} and Elena Batieva and Calmet, {Micaela Alvarez} and Bastien Llamas and Michael Schultz and Raiko Krau{\ss} and Javier Jim{\'e}nez-Echevarr{\'i}a and Michael Francken and Svetlana Shnaider and Knijff, {Peter De} and Eveline Altena and Vijver, {Katrien Van De} and Lars Fehren-Schmitz and Tung, {Tiffiny A.} and Sandra L{\"o}sch and Maria Dobrovolskaya and Nikolaj Makarov and Chris Read and Twest, {Melanie Van} and Claudia Sagona and Ramsl, {Peter C.} and Murat Akar and Yener, {K. Aslihan} and Ballestero, {Eduardo Carmona} and Francesco Cucca and Vittorio Mazzarello and Pilar Utrilla and Kurt Rademaker and Eva Fern{\'a}ndez-Dom{\'i}nguez and Douglas Baird and Patrick Semal and Lourdes M{\'a}rquez-Morf{\'i}n and Mirjana Roksandic and Hubert Steiner and Salazar-Garc{\'i}a, {Domingo Carlos} and Natalia Shishlina and Erdal, {Yilmaz Selim} and Fredrik Hallgren and Yavor Boyadzhiev and Kamen Boyadzhiev and Mario K{\"u}{\ss}ner and Duncan Sayer and P{\"a}ivi Onkamo and Robin Skeates and Manuel Rojo-Guerra and Alexandra Buzhilova and Elmira Khussainova and Djansugurova, {Leyla B.} and Beisenov, {Arman Z.} and Zainolla Samashev and Ken Massy and Marcello Mannino and Vyacheslav Moiseyev and Kristiina Mannermaa and Oleg Balanovsky and Deguilloux, {Marie France} and Sabine Reinhold and Svend Hansen and Kitov, {Egor P.} and Miroslav Dobe{\v s} and Michal Ern{\'e}e and Harald Meller and Kurt, {Alt W.} and Kay Pr{\"u}fer and Christina Warinner and Stephan Schiffels and Stockhammer, {Philipp W.} and Kirsten Bos and Cosimo Posth and Alexander Herbig and Wolfgang Haak and Johannes Krause2 and Johannes Krause2 and Arthur Kocher",

year = "2021",

month = oct,

day = "8",

doi = "10.1126/science.abi5658",

language = "English",

volume = "374",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6564",

}

Kocher, A, Papac, L, Barquera, R, Key, FM, Spyrou, MA, Hübler, R, Rohrlach2, AB, Aron, F, Stahl, R, Wissgott, A, Van Bömme, F, Pfefferkorn, M, Alissa, M, Villalba-Mouco, V, Neumann, GU, Rivollat, M, Van De Loosdrecht, MS, Majander, K, Tukhbatova, RI, Musralina, L, Ghalichi, A, Penske, S, Sabin, S, Michel, M, Gretzinger, J, Nelson, EA, Ferraz, T, Nägele, K, Parker, C, Keller, M, Guevara, EK, Feldman, M, Eisenmann, S, Skourtanioti, E, Giffin, K, Gnecchi-Ruscone, GA, Friederich, S, Schimmenti, V, Khartanovich, V, Karapetian, MK, Chaplygin, MS, Kufterin, VV, Khokhlov, AA, Chizhevsky, AA, Stashenkov, DA, Kochkina, AF, Tejedor-Rodríguez, C, De Lagrán, ÍGM, Arcusa-Magallón, H, Garrido-Pena, R, Royo-Guillén, JI, Nováček, J, Rottier, S, Kacki, S, Saintot, S, Kaverzneva, E, Belinskiy, AB, Velemínský, P, Limburský, P, Kostka, M, Loe, L, Popescu, E, Clarke, R, Lyons, A, Mortimer, R, Sajantila, A, Armas, YCD, Godoy, STH, Hernández-Zaragoza, DI, Pearson, J, Binder, D, Lefranc, P, Kantorovich, AR, Maslov, VE, Lai, L, Zoledziewska, M, Beckett, JF, Langová, M, Danielisová, A, Ingman, T, Atiénzar, GG, Ibáñez, MPDM, Romero, A, Sperduti, A, Beckett, S, Salter, SJ, Zilivinskaya, ED, Vasil'ev, DV, Heyking, KV, Burger, RL, Salazar, LC, Amkreutz, L, Navruzbekov, M, Rosenstock, E, Alonso-Fernández, C, Slavchev, V, Kalmykov, AA, Atabiev, BC, Batieva, E, Calmet, MA, Llamas, B, Schultz, M, Krauß, R, Jiménez-Echevarría, J, Francken, M, Shnaider, S, Knijff, PD, Altena, E, Vijver, KVD, Fehren-Schmitz, L, Tung, TA, Lösch, S, Dobrovolskaya, M, Makarov, N, Read, C, Twest, MV, Sagona, C, Ramsl, PC, Akar, M, Yener, KA, Ballestero, EC, Cucca, F, Mazzarello, V, Utrilla, P, Rademaker, K, Fernández-Domínguez, E, Baird, D, Semal, P, Márquez-Morfín, L, Roksandic, M, Steiner, H, Salazar-García, DC, Shishlina, N, Erdal, YS, Hallgren, F, Boyadzhiev, Y, Boyadzhiev, K, Küßner, M, Sayer, D, Onkamo, P, Skeates, R, Rojo-Guerra, M, Buzhilova, A, Khussainova, E, Djansugurova, LB, Beisenov, AZ, Samashev, Z, Massy, K, Mannino, M, Moiseyev, V, Mannermaa, K, Balanovsky, O, Deguilloux, MF, Reinhold, S, Hansen, S, Kitov, EP, Dobeš, M, Ernée, M, Meller, H, Kurt, AW, Prüfer, K, Warinner, C, Schiffels, S, Stockhammer, PW, Bos, K, Posth, C, Herbig, A, Haak, W, Krause2, J, Krause2, J & Kocher, A 2021, 'Ten millennia of hepatitis B virus evolution', Science, vol. 374, no. 6564. https://doi.org/10.1126/science.abi5658

TY - JOUR

T1 - Ten millennia of hepatitis B virus evolution

AU - Kocher, Arthur

AU - Papac, Luka

AU - Barquera, Rodrigo

AU - Key, Felix M.

AU - Spyrou, Maria A.

AU - Hübler, Ron

AU - Rohrlach2, Adam B.

AU - Aron, Franziska

AU - Stahl, Raphaela

AU - Wissgott, Antje

AU - Van Bömme, Florian

AU - Pfefferkorn, Maria

AU - Alissa, Mittnik

AU - Villalba-Mouco, Vanessa

AU - Neumann, Gunnar U.

AU - Rivollat, Maït

AU - Van De Loosdrecht, Marieke S.

AU - Majander, Kerttu

AU - Tukhbatova, Rezeda I.

AU - Musralina, Lyazzat

AU - Ghalichi, Ayshin

AU - Penske, Sandra

AU - Sabin, Susanna

AU - Michel, Megan

AU - Gretzinger, Joscha

AU - Nelson, Elizabeth A.

AU - Ferraz, Tiago

AU - Nägele, Kathrin

AU - Parker, Cody

AU - Keller, Marcel

AU - Guevara, Evelyn K.

AU - Feldman, Michal

AU - Eisenmann, Stefanie

AU - Skourtanioti, Eirini

AU - Giffin, Karen

AU - Gnecchi-Ruscone, Guido Alberto

AU - Friederich, Susanne

AU - Schimmenti, Vittoria

AU - Khartanovich, Valery

AU - Karapetian, Marina K.

AU - Chaplygin, Mikhail S.

AU - Kufterin, Vladimir V.

AU - Khokhlov, Aleksandr A.

AU - Chizhevsky, Andrey A.

AU - Stashenkov, Dmitry A.

AU - Kochkina, Anna F.

AU - Tejedor-Rodríguez, Cristina

AU - De Lagrán, Íñigo García Martínez

AU - Arcusa-Magallón, Héctor

AU - Garrido-Pena, Rafael

AU - Royo-Guillén, José Ignacio

AU - Nováček, Jan

AU - Rottier, Stéphane

AU - Kacki, Sacha

AU - Saintot, Sylvie

AU - Kaverzneva, Elena

AU - Belinskiy, Andrej B.

AU - Velemínský, Petr

AU - Limburský, Petr

AU - Kostka, Michal

AU - Loe, Louise

AU - Popescu, Elizabeth

AU - Clarke, Rachel

AU - Lyons, Alice

AU - Mortimer, Richard

AU - Sajantila, Antti

AU - Armas, Yadira Chinique De

AU - Godoy, Silvia Teresita Hernandez

AU - Hernández-Zaragoza, Diana I.

AU - Pearson, Jessica

AU - Binder, Didier

AU - Lefranc, Philippe

AU - Kantorovich, Anatoly R.

AU - Maslov, Vladimir E.

AU - Lai, Luca

AU - Zoledziewska, Magdalena

AU - Beckett, Jessica F.

AU - Langová, Michaela

AU - Danielisová, Alžběta

AU - Ingman, Tara

AU - Atiénzar, Gabriel García

AU - Ibáñez, Maria Paz De Miguel

AU - Romero, Alejandro

AU - Sperduti, Alessandra

AU - Beckett, Sophie

AU - Salter, Susannah J.

AU - Zilivinskaya, Emma D.

AU - Vasil'ev, Dmitry V.

AU - Heyking, Kristin Von

AU - Burger, Richard L.

AU - Salazar, Lucy C.

AU - Amkreutz, Luc

AU - Navruzbekov, Masnav

AU - Rosenstock, Eva

AU - Alonso-Fernández, Carmen

AU - Slavchev, Vladimir

AU - Kalmykov, Alexey A.

AU - Atabiev, Biaslan Ch

AU - Batieva, Elena

AU - Calmet, Micaela Alvarez

AU - Llamas, Bastien

AU - Schultz, Michael

AU - Krauß, Raiko

AU - Jiménez-Echevarría, Javier

AU - Francken, Michael

AU - Shnaider, Svetlana

AU - Knijff, Peter De

AU - Altena, Eveline

AU - Vijver, Katrien Van De

AU - Fehren-Schmitz, Lars

AU - Tung, Tiffiny A.

AU - Lösch, Sandra

AU - Dobrovolskaya, Maria

AU - Makarov, Nikolaj

AU - Read, Chris

AU - Twest, Melanie Van

AU - Sagona, Claudia

AU - Ramsl, Peter C.

AU - Akar, Murat

AU - Yener, K. Aslihan

AU - Ballestero, Eduardo Carmona

AU - Cucca, Francesco

AU - Mazzarello, Vittorio

AU - Utrilla, Pilar

AU - Rademaker, Kurt

AU - Fernández-Domínguez, Eva

AU - Baird, Douglas

AU - Semal, Patrick

AU - Márquez-Morfín, Lourdes

AU - Roksandic, Mirjana

AU - Steiner, Hubert

AU - Salazar-García, Domingo Carlos

AU - Shishlina, Natalia

AU - Erdal, Yilmaz Selim

AU - Hallgren, Fredrik

AU - Boyadzhiev, Yavor

AU - Boyadzhiev, Kamen

AU - Küßner, Mario

AU - Sayer, Duncan

AU - Onkamo, Päivi

AU - Skeates, Robin

AU - Rojo-Guerra, Manuel

AU - Buzhilova, Alexandra

AU - Khussainova, Elmira

AU - Djansugurova, Leyla B.

AU - Beisenov, Arman Z.

AU - Samashev, Zainolla

AU - Massy, Ken

AU - Mannino, Marcello

AU - Moiseyev, Vyacheslav

AU - Mannermaa, Kristiina

AU - Balanovsky, Oleg

AU - Deguilloux, Marie France

AU - Reinhold, Sabine

AU - Hansen, Svend

AU - Kitov, Egor P.

AU - Dobeš, Miroslav

AU - Ernée, Michal

AU - Meller, Harald

AU - Kurt, Alt W.

AU - Prüfer, Kay

AU - Warinner, Christina

AU - Schiffels, Stephan

AU - Stockhammer, Philipp W.

AU - Bos, Kirsten

AU - Posth, Cosimo

AU - Herbig, Alexander

AU - Haak, Wolfgang

AU - Krause2, Johannes

AU - Kocher, Arthur

PY - 2021/10/8

Y1 - 2021/10/8

N2 - Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.

AB - Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.

UR - http://www.scopus.com/inward/record.url?scp=85118031627&partnerID=8YFLogxK

U2 - 10.1126/science.abi5658

DO - 10.1126/science.abi5658

M3 - Article

SN - 0036-8075

VL - 374

JO - Science

JF - Science

IS - 6564

ER -

Ten millennia of hepatitis B virus evolution

Abstract

Access to Document

Other files and links

Fingerprint

Cite this