The biological and clinical significance of stromal-epithelial interactions in breast cancer

Robert McCuaig; Fan Wu; Jenny Dunn; Sudha Rao; Jane E. Dahlstrom

doi:10.1016/j.pathol.2016.10.009

The biological and clinical significance of stromal-epithelial interactions in breast cancer

Robert McCuaig, Fan Wu, Jenny Dunn, Sudha Rao^*, Jane E. Dahlstrom

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Abstract

There is evidence that an aberrant tumour microenvironment (TME) facilitates cancer development, progression, and responses to treatment. While many of the mechanisms underlying the phenotype and cancer-promoting behaviour of the TME are unknown, epigenetic mechanisms in cancer cells and the TME are thought to play important roles. As a result, cancer profiling strategies for drug and biomarker development require a thorough understanding of both the epithelial tissue compartment and the TME. This review discusses recent advances in our understanding of how cancer epithelial cells interact with their microenvironment and how this knowledge can be exploited clinically.

Original language	English
Pages (from-to)	133-140
Number of pages	8
Journal	Pathology
Volume	49
Issue number	2
DOIs	https://doi.org/10.1016/j.pathol.2016.10.009
Publication status	Published - 1 Feb 2017

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10.1016/j.pathol.2016.10.009

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title = "The biological and clinical significance of stromal-epithelial interactions in breast cancer",

abstract = "There is evidence that an aberrant tumour microenvironment (TME) facilitates cancer development, progression, and responses to treatment. While many of the mechanisms underlying the phenotype and cancer-promoting behaviour of the TME are unknown, epigenetic mechanisms in cancer cells and the TME are thought to play important roles. As a result, cancer profiling strategies for drug and biomarker development require a thorough understanding of both the epithelial tissue compartment and the TME. This review discusses recent advances in our understanding of how cancer epithelial cells interact with their microenvironment and how this knowledge can be exploited clinically.",

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author = "Robert McCuaig and Fan Wu and Jenny Dunn and Sudha Rao and Dahlstrom, {Jane E.}",

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AU - McCuaig, Robert

AU - Wu, Fan

AU - Dunn, Jenny

AU - Rao, Sudha

AU - Dahlstrom, Jane E.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - There is evidence that an aberrant tumour microenvironment (TME) facilitates cancer development, progression, and responses to treatment. While many of the mechanisms underlying the phenotype and cancer-promoting behaviour of the TME are unknown, epigenetic mechanisms in cancer cells and the TME are thought to play important roles. As a result, cancer profiling strategies for drug and biomarker development require a thorough understanding of both the epithelial tissue compartment and the TME. This review discusses recent advances in our understanding of how cancer epithelial cells interact with their microenvironment and how this knowledge can be exploited clinically.

AB - There is evidence that an aberrant tumour microenvironment (TME) facilitates cancer development, progression, and responses to treatment. While many of the mechanisms underlying the phenotype and cancer-promoting behaviour of the TME are unknown, epigenetic mechanisms in cancer cells and the TME are thought to play important roles. As a result, cancer profiling strategies for drug and biomarker development require a thorough understanding of both the epithelial tissue compartment and the TME. This review discusses recent advances in our understanding of how cancer epithelial cells interact with their microenvironment and how this knowledge can be exploited clinically.

KW - Breast cancer

KW - DNA methylation

KW - cancer associated fibroblasts

KW - cancer stem cells

KW - epi-drugs

KW - epigenetics

KW - histone

KW - tumour microenvironment

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DO - 10.1016/j.pathol.2016.10.009

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SP - 133

EP - 140

JO - Pathology

JF - Pathology

IS - 2

ER -

The biological and clinical significance of stromal-epithelial interactions in breast cancer

Abstract

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