TY - JOUR
T1 - The BRICS (Bronchiectasis Radiologically Indexed CT Score)
T2 - A Multicenter Study Score for Use in Idiopathic and Postinfective Bronchiectasis
AU - Bedi, Pallavi
AU - Chalmers, James D.
AU - Goeminne, Pieter C.
AU - Mai, Cindy
AU - Saravanamuthu, Pira
AU - Velu, Prasad Palani
AU - Cartlidge, Manjit K.
AU - Loebinger, Michael R.
AU - Jacob, Joe
AU - Kamal, Faisal
AU - Schembri, Nicola
AU - Aliberti, Stefano
AU - Hill, Uta
AU - Harrison, Mike
AU - Johnson, Christopher
AU - Screaton, Nicholas
AU - Haworth, Charles
AU - Polverino, Eva
AU - Rosales, Edmundo
AU - Torres, Antoni
AU - Benegas, Michael N.
AU - Rossi, Adriano G.
AU - Patel, Dilip
AU - Hill, Adam T.
N1 - Publisher Copyright:
© 2017 American College of Chest Physicians
PY - 2018/5
Y1 - 2018/5
N2 - Objectives: The goal of this study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis. Methods: The Bronchiectasis Radiologically Indexed CT Score (BRICS) was devised based on a multivariable analysis of the Bhalla score and its ability in predicting clinical parameters of severity. The score was then externally validated in six centers in 302 patients. Results: A total of 184 high-resolution CT scans were scored for the validation cohort. In a multiple logistic regression model, disease severity markers significantly associated with the Bhalla score were percent predicted FEV 1 , sputum purulence, and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operating-characteristic curve values for BRICS in the derivation cohort were 0.79 for percent predicted FEV 1 , 0.71 for sputum purulence, and 0.75 for hospital admissions per year; these values were 0.81, 0.70, and 0.70, respectively, in the validation cohort. Sputum free neutrophil elastase activity was significantly elevated in the group with emphysema on CT imaging. Conclusions: A simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and postinfective bronchiectasis.
AB - Objectives: The goal of this study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis. Methods: The Bronchiectasis Radiologically Indexed CT Score (BRICS) was devised based on a multivariable analysis of the Bhalla score and its ability in predicting clinical parameters of severity. The score was then externally validated in six centers in 302 patients. Results: A total of 184 high-resolution CT scans were scored for the validation cohort. In a multiple logistic regression model, disease severity markers significantly associated with the Bhalla score were percent predicted FEV 1 , sputum purulence, and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operating-characteristic curve values for BRICS in the derivation cohort were 0.79 for percent predicted FEV 1 , 0.71 for sputum purulence, and 0.75 for hospital admissions per year; these values were 0.81, 0.70, and 0.70, respectively, in the validation cohort. Sputum free neutrophil elastase activity was significantly elevated in the group with emphysema on CT imaging. Conclusions: A simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and postinfective bronchiectasis.
KW - bronchiectasis
KW - CT scan
KW - scoring system
UR - https://www.scopus.com/pages/publications/85044529328
UR - https://www-clinicalkey-com-au.virtual.anu.edu.au/#!/content/playContent/1-s2.0-S0012369217332130
U2 - 10.1016/j.chest.2017.11.033
DO - 10.1016/j.chest.2017.11.033
M3 - Article
C2 - 29247616
AN - SCOPUS:85044529328
SN - 0012-3692
VL - 153
SP - 1177
EP - 1186
JO - Chest
JF - Chest
IS - 5
ER -