TY - JOUR
T1 - The changing of the guard
T2 - The Pto/Prf receptor complex of tomato and pathogen recognition
AU - Ntoukakis, Vardis
AU - Saur, Isabel M.L.
AU - Conlan, Brendon
AU - Rathjen, John P.
PY - 2014/8
Y1 - 2014/8
N2 - One important model for disease resistance is the Prf recognition complex of tomato, which responds to different bacterial effectors. Prf incorporates a protein kinase called Pto as its recognition domain that mimics effector virulence targets, and activates resistance after interaction with specific effectors. Recent findings show that this complex is oligomeric, and reveal how this impacts mechanism. Oligomerisation brings two or more kinases into proximity, where they can phosphorylate each other after effector perception. Effector attack on one kinase activates another in trans, constituting a molecular trap for the effector. Oligomerisation of plant resistance proteins may be a general concept that broadens pathogen recognition and restricts the ability of pathogens to evolve virulence.
AB - One important model for disease resistance is the Prf recognition complex of tomato, which responds to different bacterial effectors. Prf incorporates a protein kinase called Pto as its recognition domain that mimics effector virulence targets, and activates resistance after interaction with specific effectors. Recent findings show that this complex is oligomeric, and reveal how this impacts mechanism. Oligomerisation brings two or more kinases into proximity, where they can phosphorylate each other after effector perception. Effector attack on one kinase activates another in trans, constituting a molecular trap for the effector. Oligomerisation of plant resistance proteins may be a general concept that broadens pathogen recognition and restricts the ability of pathogens to evolve virulence.
UR - http://www.scopus.com/inward/record.url?scp=84901054331&partnerID=8YFLogxK
U2 - 10.1016/j.pbi.2014.04.002
DO - 10.1016/j.pbi.2014.04.002
M3 - Review article
SN - 1369-5266
VL - 20
SP - 69
EP - 74
JO - Current Opinion in Plant Biology
JF - Current Opinion in Plant Biology
ER -