The Collaborative Cross, a community resource for the genetic analysis of complex traits

Gary A. Churchill; David C. Airey; Hooman Allayee; Joe M. Angel; Alan D. Attie; Jackson Beatty; Willam D. Beavis; John K. Belknap; Beth Bennett; Wade Berrettini; Andre Bleich; Molly Bogue; Karl W. Broman; Kari J. Buck; Ed Buckler; Margit Burmeister; Elissa J. Chesler; James M. Cheverud; Steven Clapcote; Melloni N. Cook; Roger D. Cox; John C. Crabbe; Wim E. Crusio; Ariel Darvasi; Christian F. Deschepper; R. W. Doerge; Charles R. Farber; Jiri Forejt; Daniel Gaile; Steven J. Garlow; Hartmut Geiger; Howard Gershenfeld; Terry Gordon; Jing Gu; Weikuan Gu; Gerald de Haan; Nancy L. Hayes; Craig Heller; Heinz Himmelbauer; Robert Hitzemann; Kent Hunter; Hui Chen Hsu; Fuad A. Iraqi; Boris Ivandic; Howard J. Jacob; Ritsert C. Jansen; Bastien Llamas; David G. Morris; Robert W. Williams; Min Zhang

doi:10.1038/ng1104-1133

The Collaborative Cross, a community resource for the genetic analysis of complex traits

Gary A. Churchill, David C. Airey, Hooman Allayee, Joe M. Angel, Alan D. Attie, Jackson Beatty, Willam D. Beavis, John K. Belknap, Beth Bennett, Wade Berrettini, Andre Bleich, Molly Bogue, Karl W. Broman, Kari J. Buck, Ed Buckler, Margit Burmeister, Elissa J. Chesler, James M. Cheverud, Steven Clapcote, Melloni N. CookRoger D. Cox, John C. Crabbe, Wim E. Crusio, Ariel Darvasi, Christian F. Deschepper, R. W. Doerge, Charles R. Farber, Jiri Forejt, Daniel Gaile, Steven J. Garlow, Hartmut Geiger, Howard Gershenfeld, Terry Gordon, Jing Gu, Weikuan Gu, Gerald de Haan, Nancy L. Hayes, Craig Heller, Heinz Himmelbauer, Robert Hitzemann, Kent Hunter, Hui Chen Hsu, Fuad A. Iraqi, Boris Ivandic, Howard J. Jacob, Ritsert C. Jansen, Bastien Llamas, David G. Morris, Robert W. Williams, Min Zhang

Research output: Contribution to journal › Review article › peer-review

910 Citations (Scopus)

Abstract

The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

Original language	English
Pages (from-to)	1133-1137
Number of pages	5
Journal	Nature Genetics
Volume	36
Issue number	11
DOIs	https://doi.org/10.1038/ng1104-1133
Publication status	Published - Nov 2004
Externally published	Yes

Access to Document

10.1038/ng1104-1133

Cite this

Churchill, G. A., Airey, D. C., Allayee, H., Angel, J. M., Attie, A. D., Beatty, J., Beavis, W. D., Belknap, J. K., Bennett, B., Berrettini, W., Bleich, A., Bogue, M., Broman, K. W., Buck, K. J., Buckler, E., Burmeister, M., Chesler, E. J., Cheverud, J. M., Clapcote, S., ... Zhang, M. (2004). The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics, 36(11), 1133-1137. https://doi.org/10.1038/ng1104-1133

@article{d13817eb712b4fb38adc5ad3c29e27d1,

title = "The Collaborative Cross, a community resource for the genetic analysis of complex traits",

abstract = "The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.",

author = "Churchill, {Gary A.} and Airey, {David C.} and Hooman Allayee and Angel, {Joe M.} and Attie, {Alan D.} and Jackson Beatty and Beavis, {Willam D.} and Belknap, {John K.} and Beth Bennett and Wade Berrettini and Andre Bleich and Molly Bogue and Broman, {Karl W.} and Buck, {Kari J.} and Ed Buckler and Margit Burmeister and Chesler, {Elissa J.} and Cheverud, {James M.} and Steven Clapcote and Cook, {Melloni N.} and Cox, {Roger D.} and Crabbe, {John C.} and Crusio, {Wim E.} and Ariel Darvasi and Deschepper, {Christian F.} and Doerge, {R. W.} and Farber, {Charles R.} and Jiri Forejt and Daniel Gaile and Garlow, {Steven J.} and Hartmut Geiger and Howard Gershenfeld and Terry Gordon and Jing Gu and Weikuan Gu and {de Haan}, Gerald and Hayes, {Nancy L.} and Craig Heller and Heinz Himmelbauer and Robert Hitzemann and Kent Hunter and Hsu, {Hui Chen} and Iraqi, {Fuad A.} and Boris Ivandic and Jacob, {Howard J.} and Jansen, {Ritsert C.} and Bastien Llamas and Morris, {David G.} and Williams, {Robert W.} and Min Zhang",

year = "2004",

month = nov,

doi = "10.1038/ng1104-1133",

language = "English",

volume = "36",

pages = "1133--1137",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "11",

}

Churchill, GA, Airey, DC, Allayee, H, Angel, JM, Attie, AD, Beatty, J, Beavis, WD, Belknap, JK, Bennett, B, Berrettini, W, Bleich, A, Bogue, M, Broman, KW, Buck, KJ, Buckler, E, Burmeister, M, Chesler, EJ, Cheverud, JM, Clapcote, S, Cook, MN, Cox, RD, Crabbe, JC, Crusio, WE, Darvasi, A, Deschepper, CF, Doerge, RW, Farber, CR, Forejt, J, Gaile, D, Garlow, SJ, Geiger, H, Gershenfeld, H, Gordon, T, Gu, J, Gu, W, de Haan, G, Hayes, NL, Heller, C, Himmelbauer, H, Hitzemann, R, Hunter, K, Hsu, HC, Iraqi, FA, Ivandic, B, Jacob, HJ, Jansen, RC, Llamas, B, Morris, DG, Williams, RW & Zhang, M 2004, 'The Collaborative Cross, a community resource for the genetic analysis of complex traits', Nature Genetics, vol. 36, no. 11, pp. 1133-1137. https://doi.org/10.1038/ng1104-1133

TY - JOUR

T1 - The Collaborative Cross, a community resource for the genetic analysis of complex traits

AU - Churchill, Gary A.

AU - Airey, David C.

AU - Allayee, Hooman

AU - Angel, Joe M.

AU - Attie, Alan D.

AU - Beatty, Jackson

AU - Beavis, Willam D.

AU - Belknap, John K.

AU - Bennett, Beth

AU - Berrettini, Wade

AU - Bleich, Andre

AU - Bogue, Molly

AU - Broman, Karl W.

AU - Buck, Kari J.

AU - Buckler, Ed

AU - Burmeister, Margit

AU - Chesler, Elissa J.

AU - Cheverud, James M.

AU - Clapcote, Steven

AU - Cook, Melloni N.

AU - Cox, Roger D.

AU - Crabbe, John C.

AU - Crusio, Wim E.

AU - Darvasi, Ariel

AU - Deschepper, Christian F.

AU - Doerge, R. W.

AU - Farber, Charles R.

AU - Forejt, Jiri

AU - Gaile, Daniel

AU - Garlow, Steven J.

AU - Geiger, Hartmut

AU - Gershenfeld, Howard

AU - Gordon, Terry

AU - Gu, Jing

AU - Gu, Weikuan

AU - de Haan, Gerald

AU - Hayes, Nancy L.

AU - Heller, Craig

AU - Himmelbauer, Heinz

AU - Hitzemann, Robert

AU - Hunter, Kent

AU - Hsu, Hui Chen

AU - Iraqi, Fuad A.

AU - Ivandic, Boris

AU - Jacob, Howard J.

AU - Jansen, Ritsert C.

AU - Llamas, Bastien

AU - Morris, David G.

AU - Williams, Robert W.

AU - Zhang, Min

PY - 2004/11

Y1 - 2004/11

N2 - The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

AB - The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

UR - http://www.scopus.com/inward/record.url?scp=14644441018&partnerID=8YFLogxK

U2 - 10.1038/ng1104-1133

DO - 10.1038/ng1104-1133

M3 - Review article

C2 - 15514660

AN - SCOPUS:14644441018

SN - 1061-4036

VL - 36

SP - 1133

EP - 1137

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

The Collaborative Cross, a community resource for the genetic analysis of complex traits

Abstract

Access to Document

Other files and links

Fingerprint

Cite this