The contribution of toll-like receptors to the pathogenesis of asthma

Simon Phipps, Chuan En Lam, Paul S. Foster, Klaus I. Matthaei*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    48 Citations (Scopus)


    Asthma is a major disease in the westernized world and its incidence has significantly increased over the past 40 years. Our understanding of the pathogenesis of asthma remains rudimentary, and for this reason, little has been accomplished by way of targeted intervention, either at a population level (to reduce the overall prevalence) or at an individual level (to treat the cause). Instead, the management strategy currently in use relies on broad-spectrum anti-inflammatory agents, generally glucocorticoids and long-acting β2 agonists. The recent discovery of toll-like receptors (TLRs), with their role as the initiators of the innate immune response and inflammation, suggests that modulating these receptors may be beneficial in the treatment of allergic disorders. We review here the cellular distribution of TLR in the lung and their potential contribution to the processes that promote T helper 2 (Th2) immunity and infection-induced exacerbations of allergic lung disease.

    Original languageEnglish
    Pages (from-to)463-470
    Number of pages8
    JournalImmunology and Cell Biology
    Issue number6
    Publication statusPublished - Aug 2007


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