TY - JOUR
T1 - The current understanding of precision medicine and personalised medicine in selected research disciplines
T2 - study protocol of a systematic concept analysis
AU - Brew-Sam, Nicola
AU - Parkinson, Anne
AU - Lueck, Christian
AU - Brown, Ellen
AU - Brown, Karen
AU - Bruestle, Anne
AU - Chisholm, Katrina
AU - Collins, Simone
AU - Cook, Matthew
AU - Daskalaki, Eleni
AU - Drew, Janet
AU - Ebbeck, Harry
AU - Elisha, Mark
AU - Fanning, Vanessa
AU - Henschke, Adam
AU - Herron, Jessica
AU - Matthews, Emma
AU - Murugappan, Krishnan
AU - Neshev, Dragomir
AU - Nolan, Christopher J.
AU - Pedley, Lachlan
AU - Phillips, Christine
AU - Suominen, Hanna
AU - Tricoli, Antonio
AU - Wright, Kristine
AU - Desborough, Jane
N1 - Publisher Copyright:
©
PY - 2022/9/7
Y1 - 2022/9/7
N2 - Introduction The terms precision medicine' and personalised medicine' have become key terms in health-related research and in science-related public communication. However, the application of these two concepts and their interpretation in various disciplines are heterogeneous, which also affects research translation and public awareness. This leads to confusion regarding the use and distinction of the two concepts. Our aim is to provide a snapshot of the current understanding of these concepts. Methods and analysis Our study will use Rodgers' evolutionary concept analysis to systematically examine the current understanding of the concepts precision medicine' and personalised medicine' in clinical medicine, biomedicine (incorporating genomics and bioinformatics), health services research, physics, chemistry, engineering, machine learning and artificial intelligence, and to identify their respective attributes (clusters of characteristics) and surrogate and related terms. A systematic search of the literature will be conducted for 2016-2022 using databases relevant to each of these disciplines: ACM Digital Library, CINAHL, Cochrane Library, F1000Research, IEEE Xplore, PubMed/Medline, Science Direct, Scopus and Web of Science. These are among the most representative databases for the included disciplines. We will examine similarities and differences in definitions of precision medicine' and personalised medicine' in the respective disciplines and across (sub)disciplines, including attributes of each term. This will enable us to determine how these two concepts are distinguished. Ethics and dissemination Following ethical and research standards, we will comprehensively report the methodology for a systematic analysis following Rodgers' concept analysis method. Our systematic concept analysis will contribute to the clarification of the two concepts and distinction in their application in given settings and circumstances. Such a broad concept analysis will contribute to non-systematic syntheses of the concepts, or occasional systematic reviews on one of the concepts that have been published in specific disciplines, in order to facilitate interdisciplinary communication, translational medical research and implementation science.
AB - Introduction The terms precision medicine' and personalised medicine' have become key terms in health-related research and in science-related public communication. However, the application of these two concepts and their interpretation in various disciplines are heterogeneous, which also affects research translation and public awareness. This leads to confusion regarding the use and distinction of the two concepts. Our aim is to provide a snapshot of the current understanding of these concepts. Methods and analysis Our study will use Rodgers' evolutionary concept analysis to systematically examine the current understanding of the concepts precision medicine' and personalised medicine' in clinical medicine, biomedicine (incorporating genomics and bioinformatics), health services research, physics, chemistry, engineering, machine learning and artificial intelligence, and to identify their respective attributes (clusters of characteristics) and surrogate and related terms. A systematic search of the literature will be conducted for 2016-2022 using databases relevant to each of these disciplines: ACM Digital Library, CINAHL, Cochrane Library, F1000Research, IEEE Xplore, PubMed/Medline, Science Direct, Scopus and Web of Science. These are among the most representative databases for the included disciplines. We will examine similarities and differences in definitions of precision medicine' and personalised medicine' in the respective disciplines and across (sub)disciplines, including attributes of each term. This will enable us to determine how these two concepts are distinguished. Ethics and dissemination Following ethical and research standards, we will comprehensively report the methodology for a systematic analysis following Rodgers' concept analysis method. Our systematic concept analysis will contribute to the clarification of the two concepts and distinction in their application in given settings and circumstances. Such a broad concept analysis will contribute to non-systematic syntheses of the concepts, or occasional systematic reviews on one of the concepts that have been published in specific disciplines, in order to facilitate interdisciplinary communication, translational medical research and implementation science.
KW - Protocols & guidelines
KW - QUALITATIVE RESEARCH
KW - STATISTICS & RESEARCH METHODS
UR - http://www.scopus.com/inward/record.url?scp=85138154490&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2021-060326
DO - 10.1136/bmjopen-2021-060326
M3 - Article
SN - 2044-6055
VL - 12
JO - BMJ Open
JF - BMJ Open
IS - 9
M1 - e060326
ER -