The effect of season on cytokine expression in multiple sclerosis and healthy subjects

Niall Stewart; Bruce Taylor; Anne Louise Ponsonby; Fotini Pittas; Ingrid van der Mei; Greg Woods; Haydn Walters

doi:10.1016/j.jneuroim.2007.06.012

The effect of season on cytokine expression in multiple sclerosis and healthy subjects

Niall Stewart^*, Bruce Taylor, Anne Louise Ponsonby, Fotini Pittas, Ingrid van der Mei, Greg Woods, Haydn Walters

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

We measured the levels of IFNγ, TNFα, Il-4 and Il-10 produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from healthy people, and those with the relapse/remitting form of multiple sclerosis. Blood was taken in summer and winter. Healthy people had a summer excess of Il-4, Il-10 and TNFα, and a winter excess of IFNγ. Untreated MS cases had a summer excess of Il-10, whereas those treated with Interferon-beta had lower levels of all cytokines, and displayed no seasonal effect. Crown

Original language	English
Pages (from-to)	181-186
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	188
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2007.06.012
Publication status	Published - Aug 2007

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10.1016/j.jneuroim.2007.06.012

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title = "The effect of season on cytokine expression in multiple sclerosis and healthy subjects",

abstract = "We measured the levels of IFNγ, TNFα, Il-4 and Il-10 produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from healthy people, and those with the relapse/remitting form of multiple sclerosis. Blood was taken in summer and winter. Healthy people had a summer excess of Il-4, Il-10 and TNFα, and a winter excess of IFNγ. Untreated MS cases had a summer excess of Il-10, whereas those treated with Interferon-beta had lower levels of all cytokines, and displayed no seasonal effect. Crown",

keywords = "Cytokines, Multiple sclerosis, Season",

author = "Niall Stewart and Bruce Taylor and Ponsonby, {Anne Louise} and Fotini Pittas and {van der Mei}, Ingrid and Greg Woods and Haydn Walters",

year = "2007",

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AU - Stewart, Niall

AU - Taylor, Bruce

AU - Ponsonby, Anne Louise

AU - Pittas, Fotini

AU - van der Mei, Ingrid

AU - Woods, Greg

AU - Walters, Haydn

PY - 2007/8

Y1 - 2007/8

N2 - We measured the levels of IFNγ, TNFα, Il-4 and Il-10 produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from healthy people, and those with the relapse/remitting form of multiple sclerosis. Blood was taken in summer and winter. Healthy people had a summer excess of Il-4, Il-10 and TNFα, and a winter excess of IFNγ. Untreated MS cases had a summer excess of Il-10, whereas those treated with Interferon-beta had lower levels of all cytokines, and displayed no seasonal effect. Crown

AB - We measured the levels of IFNγ, TNFα, Il-4 and Il-10 produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from healthy people, and those with the relapse/remitting form of multiple sclerosis. Blood was taken in summer and winter. Healthy people had a summer excess of Il-4, Il-10 and TNFα, and a winter excess of IFNγ. Untreated MS cases had a summer excess of Il-10, whereas those treated with Interferon-beta had lower levels of all cytokines, and displayed no seasonal effect. Crown

KW - Cytokines

KW - Multiple sclerosis

KW - Season

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DO - 10.1016/j.jneuroim.2007.06.012

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VL - 188

SP - 181

EP - 186

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

The effect of season on cytokine expression in multiple sclerosis and healthy subjects

Abstract

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