TY - JOUR
T1 - The effect of zinc supplementation on pregnancy outcome
T2 - A randomized controlled trial
AU - Zahiri Sorouri, Ziba
AU - Sadeghi, Hossein
AU - Pourmarzi, Davoud
N1 - Publisher Copyright:
© 2015 Taylor & Francis.
PY - 2016/7/2
Y1 - 2016/7/2
N2 - Objectives: This study aimed to evaluate the impact of prenatal zinc supplementation on pregnancy outcomes.Methods: A randomized controlled trial with equal randomization (1:1) was conducted on 540 pregnant women in Rasht, Iran from January 2010 to January 2012. Participants were randomly assigned to receive a daily supplement including 400-g folic acid and 30-mg ferrous sulfate, with or without 15-mg zinc sulfate from the 16th week of gestation until delivery.Results: Mean difference of birth weight between the two groups was not significantly different (3262 ± 390 g in the zinc, 3272 ± 403 g in the no-zinc groups) (p = 0.780). There were no significant differences between the two groups in terms of means of head circumference (p = 0.999), length (p = 0.848), and gestational age at birth (p = 0.057) incidences of low birth weight (p = 0.863), macrosomia (p = 0.642), and the Apgar score >7 at 5 min (p = 0.999), incidences of preterm delivery (p = 0.999), pre-eclampsia (p = 0.835), premature rupture of membranes (p = 0.630), and spontaneous abortion (p = 0.772). Abruption of placenta, amnionitis, stillbirth, and intrauterine death were not observed.Conclusion: Based on our findings, 15-mg zinc supplementation daily from 16 weeks of pregnancy until delivery cannot improve pregnancy outcomes.
AB - Objectives: This study aimed to evaluate the impact of prenatal zinc supplementation on pregnancy outcomes.Methods: A randomized controlled trial with equal randomization (1:1) was conducted on 540 pregnant women in Rasht, Iran from January 2010 to January 2012. Participants were randomly assigned to receive a daily supplement including 400-g folic acid and 30-mg ferrous sulfate, with or without 15-mg zinc sulfate from the 16th week of gestation until delivery.Results: Mean difference of birth weight between the two groups was not significantly different (3262 ± 390 g in the zinc, 3272 ± 403 g in the no-zinc groups) (p = 0.780). There were no significant differences between the two groups in terms of means of head circumference (p = 0.999), length (p = 0.848), and gestational age at birth (p = 0.057) incidences of low birth weight (p = 0.863), macrosomia (p = 0.642), and the Apgar score >7 at 5 min (p = 0.999), incidences of preterm delivery (p = 0.999), pre-eclampsia (p = 0.835), premature rupture of membranes (p = 0.630), and spontaneous abortion (p = 0.772). Abruption of placenta, amnionitis, stillbirth, and intrauterine death were not observed.Conclusion: Based on our findings, 15-mg zinc supplementation daily from 16 weeks of pregnancy until delivery cannot improve pregnancy outcomes.
KW - Birth weight
KW - maternal outcome
KW - neonatal outcome
KW - zinc supplementation
UR - http://www.scopus.com/inward/record.url?scp=84941243265&partnerID=8YFLogxK
U2 - 10.3109/14767058.2015.1079615
DO - 10.3109/14767058.2015.1079615
M3 - Article
SN - 1476-7058
VL - 29
SP - 2194
EP - 2198
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
IS - 13
ER -