TY - JOUR
T1 - The Effects of the Alkaloid Tambjamine J on Mice Implanted with Sarcoma 180 Tumor Cells
AU - Barros-Nepomuceno, Francisco Washington A.
AU - de Araújo Viana, Daniel
AU - Pinheiro, Daniel Pascoalino
AU - de Cássia Evangelista de Oliveira, Fátima
AU - Magalhães Ferreira, Jamile
AU - Maria, Maria Goretti
AU - Ma, Xinghua
AU - Cavalcanti, Bruno Coêlho
AU - Pessoa, Claudia
AU - Banwell, Martin G.
N1 - Publisher Copyright:
© 2020 Wiley-VCH GmbH
PY - 2021/1/19
Y1 - 2021/1/19
N2 - The tambjamines are a small group of bipyrrolic alkaloids that, collectively, display a significant range of biological activities including antitumor, antimicrobial and immunosuppressive properties. The key objective of the present study was to undertake preclinical assessments of tambjamine J (T-J) so as to determine its in vivo antitumor effects. To that end, sarcoma 180 cells were transplanted in mice and the impacts of the title compound then evaluated using a range of protocols including hematological, biochemical, histopathological, genotoxic and clastogenic assays. As a result it was established that this alkaloid has a significant therapeutic window and effectively reduces tumor growth (by 40 % and 79 % at doses of 10 and 20 mg/kg/day, respectively). In this regard it displays similar antitumor activity to the anticancer agent cyclophosphamide and alters animal weight in an analogous manner.
AB - The tambjamines are a small group of bipyrrolic alkaloids that, collectively, display a significant range of biological activities including antitumor, antimicrobial and immunosuppressive properties. The key objective of the present study was to undertake preclinical assessments of tambjamine J (T-J) so as to determine its in vivo antitumor effects. To that end, sarcoma 180 cells were transplanted in mice and the impacts of the title compound then evaluated using a range of protocols including hematological, biochemical, histopathological, genotoxic and clastogenic assays. As a result it was established that this alkaloid has a significant therapeutic window and effectively reduces tumor growth (by 40 % and 79 % at doses of 10 and 20 mg/kg/day, respectively). In this regard it displays similar antitumor activity to the anticancer agent cyclophosphamide and alters animal weight in an analogous manner.
UR - http://www.scopus.com/inward/record.url?scp=85093844082&partnerID=8YFLogxK
U2 - 10.1002/cmdc.202000387
DO - 10.1002/cmdc.202000387
M3 - Article
SN - 1860-7179
VL - 16
SP - 420
EP - 428
JO - ChemMedChem
JF - ChemMedChem
IS - 2
ER -