TY - JOUR
T1 - The Emerging Role of Gas Plasma in Oncotherapy
AU - Dai, Xiaofeng
AU - Bazaka, Kateryna
AU - Richard, Derek J.
AU - Thompson, Erik (Rik) W.
AU - Ostrikov, Kostya (Ken)
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/11
Y1 - 2018/11
N2 - Atmospheric pressure gas plasmas are emerging as a promising treatment in cancer that can supplement the existing set of treatment modalities and, when combined with other therapies, enhance their selectivity and efficacy against resistant cancers. With further optimisation in production and administration of plasma treatment, plasma-enabled therapy has a strong potential to mature as a tool for selectively curing highly resistant solid tumours. Although intense preclinical studies have been conducted to exploit the unique traits of plasma as an oncotherapy, few clinical studies are underway. This review identifies types of cancers and patient groups that most likely benefit from plasma oncotherapy, to introduce clinical practitioners to plasma therapy and accelerate the speed of translating plasma for cancer control in clinics.
AB - Atmospheric pressure gas plasmas are emerging as a promising treatment in cancer that can supplement the existing set of treatment modalities and, when combined with other therapies, enhance their selectivity and efficacy against resistant cancers. With further optimisation in production and administration of plasma treatment, plasma-enabled therapy has a strong potential to mature as a tool for selectively curing highly resistant solid tumours. Although intense preclinical studies have been conducted to exploit the unique traits of plasma as an oncotherapy, few clinical studies are underway. This review identifies types of cancers and patient groups that most likely benefit from plasma oncotherapy, to introduce clinical practitioners to plasma therapy and accelerate the speed of translating plasma for cancer control in clinics.
KW - chemotherapy
KW - cold atmospheric plasma
KW - multimodality therapy
KW - oncotherapy
KW - radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=85050072993&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2018.06.010
DO - 10.1016/j.tibtech.2018.06.010
M3 - Review article
C2 - 30033340
AN - SCOPUS:85050072993
SN - 0167-7799
VL - 36
SP - 1183
EP - 1198
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 11
ER -