The first electrochemical study of epidithiopiperazine-2,5-diones, a special class of α,α′-disulfide bridged cyclic dipeptides

Christina L.L. Chai; Graham A. Heath; Paul B. Huleatt; Gavin A. O'Shea

doi:10.1039/a809266d

The first electrochemical study of epidithiopiperazine-2,5-diones, a special class of α,α′-disulfide bridged cyclic dipeptides

Christina L.L. Chai, Graham A. Heath, Paul B. Huleatt, Gavin A. O'Shea

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Polarographic studies of 3,6-epidithiopiperazine-2,5-diones (ETP) including naturally occurring gliotoxin and simple synthetic analogues are pertinent to understanding their biological action; coulometric measurements on 1,4-diethyl ETP in acetonitrile establish the existence of a ready one-electron reduction overall, in sharp contrast to the familiar two-electron cleavage of acyclic disulfides.

Original language	English
Pages (from-to)	389-391
Number of pages	3
Journal	Journal of the Chemical Society. Perkin Transactions 2
Issue number	3
DOIs	https://doi.org/10.1039/a809266d
Publication status	Published - Mar 1999

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abstract = "Polarographic studies of 3,6-epidithiopiperazine-2,5-diones (ETP) including naturally occurring gliotoxin and simple synthetic analogues are pertinent to understanding their biological action; coulometric measurements on 1,4-diethyl ETP in acetonitrile establish the existence of a ready one-electron reduction overall, in sharp contrast to the familiar two-electron cleavage of acyclic disulfides.",

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AU - O'Shea, Gavin A.

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The first electrochemical study of epidithiopiperazine-2,5-diones, a special class of α,α′-disulfide bridged cyclic dipeptides

Abstract

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