The first electrochemical study of epidithiopiperazine-2,5-diones, a special class of α,α′-disulfide bridged cyclic dipeptides

Christina L.L. Chai; Graham A. Heath; Paul B. Huleatt; Gavin A. O'Shea

doi:10.1039/a809266d

The first electrochemical study of epidithiopiperazine-2,5-diones, a special class of α,α′-disulfide bridged cyclic dipeptides

Christina L.L. Chai, Graham A. Heath, Paul B. Huleatt, Gavin A. O'Shea

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Polarographic studies of 3,6-epidithiopiperazine-2,5-diones (ETP) including naturally occurring gliotoxin and simple synthetic analogues are pertinent to understanding their biological action; coulometric measurements on 1,4-diethyl ETP in acetonitrile establish the existence of a ready one-electron reduction overall, in sharp contrast to the familiar two-electron cleavage of acyclic disulfides.

Original language	English
Pages (from-to)	389-391
Number of pages	3
Journal	Journal of the Chemical Society. Perkin Transactions 2
Issue number	3
DOIs	https://doi.org/10.1039/a809266d
Publication status	Published - Mar 1999

Access to Document

10.1039/a809266d

Cite this

@article{262b4562f5b941ebb276131f2d325987,

title = "The first electrochemical study of epidithiopiperazine-2,5-diones, a special class of α,α′-disulfide bridged cyclic dipeptides",

abstract = "Polarographic studies of 3,6-epidithiopiperazine-2,5-diones (ETP) including naturally occurring gliotoxin and simple synthetic analogues are pertinent to understanding their biological action; coulometric measurements on 1,4-diethyl ETP in acetonitrile establish the existence of a ready one-electron reduction overall, in sharp contrast to the familiar two-electron cleavage of acyclic disulfides.",

author = "Chai, \{Christina L.L.\} and Heath, \{Graham A.\} and Huleatt, \{Paul B.\} and O'Shea, \{Gavin A.\}",

year = "1999",

month = mar,

doi = "10.1039/a809266d",

language = "English",

pages = "389--391",

journal = "Journal of the Chemical Society. Perkin Transactions 2",

issn = "0300-9580",

publisher = "Chemical Society",

number = "3",

}

TY - JOUR

T1 - The first electrochemical study of epidithiopiperazine-2,5-diones, a special class of α,α′-disulfide bridged cyclic dipeptides

AU - Chai, Christina L.L.

AU - Heath, Graham A.

AU - Huleatt, Paul B.

AU - O'Shea, Gavin A.

PY - 1999/3

Y1 - 1999/3

N2 - Polarographic studies of 3,6-epidithiopiperazine-2,5-diones (ETP) including naturally occurring gliotoxin and simple synthetic analogues are pertinent to understanding their biological action; coulometric measurements on 1,4-diethyl ETP in acetonitrile establish the existence of a ready one-electron reduction overall, in sharp contrast to the familiar two-electron cleavage of acyclic disulfides.

AB - Polarographic studies of 3,6-epidithiopiperazine-2,5-diones (ETP) including naturally occurring gliotoxin and simple synthetic analogues are pertinent to understanding their biological action; coulometric measurements on 1,4-diethyl ETP in acetonitrile establish the existence of a ready one-electron reduction overall, in sharp contrast to the familiar two-electron cleavage of acyclic disulfides.

UR - https://www.scopus.com/pages/publications/0041633463

U2 - 10.1039/a809266d

DO - 10.1039/a809266d

M3 - Article

SN - 0300-9580

SP - 389

EP - 391

JO - Journal of the Chemical Society. Perkin Transactions 2

JF - Journal of the Chemical Society. Perkin Transactions 2

IS - 3

ER -

The first electrochemical study of epidithiopiperazine-2,5-diones, a special class of α,α′-disulfide bridged cyclic dipeptides

Abstract

Access to Document

Other files and links

Fingerprint

Cite this