The frequently overlooked importance of solvent in free radical syntheses

Grzegorz Litwinienko; A. L.J. Beckwith; K. U. Ingold

doi:10.1039/c1cs15007c

The frequently overlooked importance of solvent in free radical syntheses

Grzegorz Litwinienko^*, A. L.J. Beckwith, K. U. Ingold

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

This tutorial review is designed to dispel the myth, still believed by many synthetic organic chemists, that radical-based syntheses are free from significant solvent effects. However, many synthetically valuable radical reactions do exhibit large kinetic solvent effects. It is therefore important to select the solvent for any proposed radical synthesis with considerable care if good product yields are to be achieved.

Original language	English
Pages (from-to)	2157-2163
Number of pages	7
Journal	Chemical Society Reviews
Volume	40
Issue number	5
DOIs	https://doi.org/10.1039/c1cs15007c
Publication status	Published - 18 Apr 2011

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AB - This tutorial review is designed to dispel the myth, still believed by many synthetic organic chemists, that radical-based syntheses are free from significant solvent effects. However, many synthetically valuable radical reactions do exhibit large kinetic solvent effects. It is therefore important to select the solvent for any proposed radical synthesis with considerable care if good product yields are to be achieved.

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The frequently overlooked importance of solvent in free radical syntheses

Abstract

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