The functional scope of plant microRNA-mediated silencing

Junyan Li, Marlene Reichel, Yanjiao Li, Anthony A. Millar*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    45 Citations (Scopus)

    Abstract

    Deep sequencing has identified a complex set of plant miRNAs that potentially regulates many target genes of high complementarity. Furthermore, the discovery that many plant miRNAs work through a translational repression mechanism, along with the identification of noncanonical targets, has encouraged bioinformatic searches with less stringent parameters, identifying an even wider range of potential targets. Together, these findings suggest that any given plant miRNA family may regulate a highly diverse set of mRNAs. Here we present evolutionary, genetic, and mechanistic evidence that opposes this idea but instead suggests that families of sequence-related miRNAs regulate very few functionally related targets. We propose that complexities beyond complementarity impact plant miRNA target recognition, possibly explaining the current disparity between bioinformatic prediction and functional evidence.

    Original languageEnglish
    Pages (from-to)750-756
    Number of pages7
    JournalTrends in Plant Science
    Volume19
    Issue number12
    DOIs
    Publication statusPublished - 1 Dec 2014

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