The great repression: Chromatin and cryptic transcription

Bianca P. Hennig; Tamás Fischer

doi:10.4161/trns.24884

The great repression: Chromatin and cryptic transcription

Bianca P. Hennig, Tamás Fischer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The eukaryotic chromatin structure is essential in correctly defining transcription units. Impairing this structure can activate cryptic promoters, and lead to the accumulation of aberrant RNA transcripts. Here we discuss critical pathways that are responsible for the repression of cryptic transcription and the maintenance of genome integrity.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	Transcription
Volume	4
Issue number	3
DOIs	https://doi.org/10.4161/trns.24884
Publication status	Published - 2013
Externally published	Yes

Access to Document

10.4161/trns.24884

Cite this

@article{9072fae34d8846fa89c00dac0da921f1,

title = "The great repression: Chromatin and cryptic transcription",

abstract = "The eukaryotic chromatin structure is essential in correctly defining transcription units. Impairing this structure can activate cryptic promoters, and lead to the accumulation of aberrant RNA transcripts. Here we discuss critical pathways that are responsible for the repression of cryptic transcription and the maintenance of genome integrity.",

keywords = "Chromatin, Cryptic promoters, Cryptic transcription, Histone modifications, Nucleosomes, ncRNA",

author = "Hennig, {Bianca P.} and Tam{\'a}s Fischer",

year = "2013",

doi = "10.4161/trns.24884",

language = "English",

volume = "4",

pages = "97--101",

journal = "Transcription",

issn = "2154-1264",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - The great repression

T2 - Chromatin and cryptic transcription

AU - Hennig, Bianca P.

AU - Fischer, Tamás

PY - 2013

Y1 - 2013

N2 - The eukaryotic chromatin structure is essential in correctly defining transcription units. Impairing this structure can activate cryptic promoters, and lead to the accumulation of aberrant RNA transcripts. Here we discuss critical pathways that are responsible for the repression of cryptic transcription and the maintenance of genome integrity.

AB - The eukaryotic chromatin structure is essential in correctly defining transcription units. Impairing this structure can activate cryptic promoters, and lead to the accumulation of aberrant RNA transcripts. Here we discuss critical pathways that are responsible for the repression of cryptic transcription and the maintenance of genome integrity.

KW - Chromatin

KW - Cryptic promoters

KW - Cryptic transcription

KW - Histone modifications

KW - Nucleosomes

KW - ncRNA

UR - http://www.scopus.com/inward/record.url?scp=84877893601&partnerID=8YFLogxK

U2 - 10.4161/trns.24884

DO - 10.4161/trns.24884

M3 - Article

SN - 2154-1264

VL - 4

SP - 97

EP - 101

JO - Transcription

JF - Transcription

IS - 3

ER -

The great repression: Chromatin and cryptic transcription

Abstract

Access to Document

Other files and links

Fingerprint

Cite this