The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

Valeska P. Ting; Marc Schmidtmann; Paul F. Henry; Sandie E. Dann; Jenna L. Crisp; Chick C. Wilson; Mark T. Weller

doi:10.1039/c0md00093k

The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

Valeska P. Ting, Marc Schmidtmann, Paul F. Henry, Sandie E. Dann, Jenna L. Crisp, Chick C. Wilson, Mark T. Weller

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The hydrations of the excipients stable α-lactose (Lα_s), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.

Original language	English
Pages (from-to)	345-348
Number of pages	4
Journal	MedChemComm
Volume	1
Issue number	5
DOIs	https://doi.org/10.1039/c0md00093k
Publication status	Published - Dec 2010
Externally published	Yes

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title = "The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction",

abstract = "The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.",

author = "Ting, {Valeska P.} and Marc Schmidtmann and Henry, {Paul F.} and Dann, {Sandie E.} and Crisp, {Jenna L.} and Wilson, {Chick C.} and Weller, {Mark T.}",

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doi = "10.1039/c0md00093k",

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AU - Ting, Valeska P.

AU - Schmidtmann, Marc

AU - Henry, Paul F.

AU - Dann, Sandie E.

AU - Crisp, Jenna L.

AU - Wilson, Chick C.

AU - Weller, Mark T.

PY - 2010/12

Y1 - 2010/12

N2 - The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.

AB - The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.

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U2 - 10.1039/c0md00093k

DO - 10.1039/c0md00093k

M3 - Article

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SP - 345

EP - 348

JO - MedChemComm

JF - MedChemComm

IS - 5

ER -

The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

Abstract

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