The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

Valeska P. Ting; Marc Schmidtmann; Paul F. Henry; Sandie E. Dann; Jenna L. Crisp; Chick C. Wilson; Mark T. Weller

doi:10.1039/c0md00093k

The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

Valeska P. Ting
, Marc Schmidtmann
, Paul F. Henry
, Sandie E. Dann
, Jenna L. Crisp
, Chick C. Wilson
, Mark T. Weller

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The hydrations of the excipients stable α-lactose (Lα_s), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.

Original language	English
Pages (from-to)	345-348
Number of pages	4
Journal	MedChemComm
Volume	1
Issue number	5
DOIs	https://doi.org/10.1039/c0md00093k
Publication status	Published - Dec 2010
Externally published	Yes

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title = "The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction",

abstract = "The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.",

author = "Ting, \{Valeska P.\} and Marc Schmidtmann and Henry, \{Paul F.\} and Dann, \{Sandie E.\} and Crisp, \{Jenna L.\} and Wilson, \{Chick C.\} and Weller, \{Mark T.\}",

year = "2010",

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doi = "10.1039/c0md00093k",

language = "English",

volume = "1",

pages = "345--348",

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T1 - The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

AU - Ting, Valeska P.

AU - Schmidtmann, Marc

AU - Henry, Paul F.

AU - Dann, Sandie E.

AU - Crisp, Jenna L.

AU - Wilson, Chick C.

AU - Weller, Mark T.

PY - 2010/12

Y1 - 2010/12

N2 - The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.

AB - The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.

UR - https://www.scopus.com/pages/publications/79955004364

U2 - 10.1039/c0md00093k

DO - 10.1039/c0md00093k

M3 - Article

SN - 2040-2503

VL - 1

SP - 345

EP - 348

JO - MedChemComm

JF - MedChemComm

IS - 5

ER -

The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

Abstract

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