The metabolism of anabolic-androgenic steroids in the greyhound

Andrew R. McKinney; Adam T. Cawley; E. Bruce Young; Carmel M. Kerwick; Karen Cunnington; Rhiannon T. Stewart; Joseph I. Ambrus; Anthony C. Willis; Malcolm D. McLeod

doi:10.4155/bio.13.40

The metabolism of anabolic-androgenic steroids in the greyhound

Andrew R. McKinney^*, Adam T. Cawley, E. Bruce Young, Carmel M. Kerwick, Karen Cunnington, Rhiannon T. Stewart, Joseph I. Ambrus, Anthony C. Willis, Malcolm D. McLeod

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Background: Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered human and veterinary AASs available in the region. Results: Canine metabolic data are presented for the AASs boldenone, danazol, ethylestrenol, mesterolone, methandriol, nandrolone and norethandrolone. The principal Phase I metabolic processes observed were the reduction of A-ring unsaturations and/or 3-ketones with either 3α,5- or 3,5α-stereochemistry, the oxidation of secondary 17-hydroxyl groups and 16α-hydroxylation. The Phase II -glucuronylation of sterol metabolites was extensive. Conclusion: The presented data have enabled the effective analysis of AASs and their metabolites in competition greyhound urine samples.

Original language	English
Pages (from-to)	769-781
Number of pages	13
Journal	Bioanalysis
Volume	5
Issue number	7
DOIs	https://doi.org/10.4155/bio.13.40
Publication status	Published - Apr 2013

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10.4155/bio.13.40

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title = "The metabolism of anabolic-androgenic steroids in the greyhound",

abstract = "Background: Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered human and veterinary AASs available in the region. Results: Canine metabolic data are presented for the AASs boldenone, danazol, ethylestrenol, mesterolone, methandriol, nandrolone and norethandrolone. The principal Phase I metabolic processes observed were the reduction of A-ring unsaturations and/or 3-ketones with either 3α,5- or 3,5α-stereochemistry, the oxidation of secondary 17-hydroxyl groups and 16α-hydroxylation. The Phase II -glucuronylation of sterol metabolites was extensive. Conclusion: The presented data have enabled the effective analysis of AASs and their metabolites in competition greyhound urine samples.",

author = "McKinney, {Andrew R.} and Cawley, {Adam T.} and Young, {E. Bruce} and Kerwick, {Carmel M.} and Karen Cunnington and Stewart, {Rhiannon T.} and Ambrus, {Joseph I.} and Willis, {Anthony C.} and McLeod, {Malcolm D.}",

year = "2013",

month = apr,

doi = "10.4155/bio.13.40",

language = "English",

volume = "5",

pages = "769--781",

journal = "Bioanalysis",

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T1 - The metabolism of anabolic-androgenic steroids in the greyhound

AU - McKinney, Andrew R.

AU - Cawley, Adam T.

AU - Young, E. Bruce

AU - Kerwick, Carmel M.

AU - Cunnington, Karen

AU - Stewart, Rhiannon T.

AU - Ambrus, Joseph I.

AU - Willis, Anthony C.

AU - McLeod, Malcolm D.

PY - 2013/4

Y1 - 2013/4

N2 - Background: Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered human and veterinary AASs available in the region. Results: Canine metabolic data are presented for the AASs boldenone, danazol, ethylestrenol, mesterolone, methandriol, nandrolone and norethandrolone. The principal Phase I metabolic processes observed were the reduction of A-ring unsaturations and/or 3-ketones with either 3α,5- or 3,5α-stereochemistry, the oxidation of secondary 17-hydroxyl groups and 16α-hydroxylation. The Phase II -glucuronylation of sterol metabolites was extensive. Conclusion: The presented data have enabled the effective analysis of AASs and their metabolites in competition greyhound urine samples.

AB - Background: Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered human and veterinary AASs available in the region. Results: Canine metabolic data are presented for the AASs boldenone, danazol, ethylestrenol, mesterolone, methandriol, nandrolone and norethandrolone. The principal Phase I metabolic processes observed were the reduction of A-ring unsaturations and/or 3-ketones with either 3α,5- or 3,5α-stereochemistry, the oxidation of secondary 17-hydroxyl groups and 16α-hydroxylation. The Phase II -glucuronylation of sterol metabolites was extensive. Conclusion: The presented data have enabled the effective analysis of AASs and their metabolites in competition greyhound urine samples.

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U2 - 10.4155/bio.13.40

DO - 10.4155/bio.13.40

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VL - 5

SP - 769

EP - 781

JO - Bioanalysis

JF - Bioanalysis

IS - 7

ER -

The metabolism of anabolic-androgenic steroids in the greyhound

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