The prevalence of mental health disorders among young adults who use amphetamine-type stimulants, compared to young adults who do not

Introduction and Aims: There is a lack of evidence regarding mental health disorder prevalence in people who use amphetamine-type stimulants (ATS). This study compares prevalence in Australian young adults who used ATS and young adults who had never used, and examines potential predictors. Design and Methods: Population-based sampling was used to recruit young adults who used ATS (n = 224) and young adults who had never used ATS (n = 125). Thirty-day prevalence of major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder (PD), post-traumatic stress disorder (PTSD) and mania/hypomania were assessed using the Composite International Diagnostic Interview Short Scale. Adjusted prevalence ratios (APR) of mental disorders in people who used ATS and the comparison group were examined, and a prediction model was developed for people who used ATS. Results: We found higher prevalence of PD (APR 4.67, 95% confidence interval [CI] 1.14–19.07, P = 0.032) and PTSD (APR 1.68, 95% CI 1.10–2.55, P = 0.016) in people who used ATS, compared to the comparison group, adjusting for sociodemographic variables. Baseline methamphetamine use was positively associated with MDD (ARR 6.45, 95% CI 1.51–27.59, P = 0.012) and GAD (ARR 2.76, 95% CI 1.52–5.02, P = 0.001). Baseline ecstasy use was negatively associated with GAD (ARR 0.52, 95% CI 0.30–0.92, P = 0.025) and PD (ARR 0.15, 95% CI 0.05–0.48, P = 0.001). Discussion and Conclusion: PTSD and PD appear to be more common in young adults who use ATS. However, the relationship between ATS use and mental disorders is complex, with divergent patterns of association for ecstasy and methamphetamine use. Mental health screening in people using ATS may improve treatment outcomes.