Abstract
The evidence supporting the reverse transcriptase model of somatic hypermutation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermutation pattern in the human BCL- 6 gene can be interpreted in terms of the reverse transcriptase model and the notion of feedback of somatically mutated sequences to the germline over evolutionary time.
| Original language | English |
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| Pages (from-to) | 61-66 |
| Number of pages | 6 |
| Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
| Volume | 355 |
| Issue number | 1405 |
| Publication status | Published - 29 Jan 2001 |
| Externally published | Yes |