The role of autoantigens in autoimmune disease

Simonetta Mocci, Kevin Lafferty, Maureen Howard

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


Many autoantigens have been identified in human patients and in rodent models. In numerous experimental settings, these autoantigens or related autoreactive lymphocytes can transfer autoimmunity. Although autoreactivity spreads to new epitopes during the course of disease, single-epitope-specific therapies show considerable efficacy in multi-epitope-induced models of autoimmunity. These observations may indicate that epitope-specific therapies operate at the level of regulating mechanisms of immune tolerance rather than exerting a direct effect on autoreactive T lymphocytes.

Original languageEnglish
Pages (from-to)725-730
Number of pages6
JournalCurrent Opinion in Immunology
Issue number6
Publication statusPublished - 2000
Externally publishedYes


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