The role of eosinophils in parasitic helminth infections: Insights from genetically modified mice

C. A. Behm*, K. S. Ovington

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    176 Citations (Scopus)

    Abstract

    Eosinophilia - an increase in the number of eosinophils in the blood or tissues - has historically been recognized as a distinctive feature of helminth infections in mammals. Yet the precise functions of these cells are still poorly understood. Many scientists consider that their primary function is protection against parasites, although there is little unequivocal in vivo evidence to prove this. Eosinophils are also responsible for considerable pathology in mammals because they are inevitably present in large numbers in inflammatory lesions associated with helminth infections or allergic conditions. In this review, Carolyn Behm and Karen Ovington outline some of the cellular and biological properties of eosinophils and evaluate the evidence for their role(s) in parasitic infections. Copyright (C) 2000 Elsevier Science Ltd.

    Original languageEnglish
    Pages (from-to)202-209
    Number of pages8
    JournalParasitology Today
    Volume16
    Issue number5
    DOIs
    Publication statusPublished - 1 May 2000

    Fingerprint

    Dive into the research topics of 'The role of eosinophils in parasitic helminth infections: Insights from genetically modified mice'. Together they form a unique fingerprint.

    Cite this