The shape of things to come. Mapping spatiotemporal progression of striatal morphology in Huntington disease: The IMAGE-HD study

Fiona A. Wilkes; David Jakabek; Mark Walterfang; Dennis Velakoulis; Govinda R. Poudel; Julie C. Stout; Phyllis Chua; Gary F. Egan; Jeffrey C.L. Looi; Nellie Georgiou-Karistianis

doi:10.1016/j.pscychresns.2023.111717

The shape of things to come. Mapping spatiotemporal progression of striatal morphology in Huntington disease: The IMAGE-HD study

Fiona A. Wilkes^*, David Jakabek, Mark Walterfang, Dennis Velakoulis, Govinda R. Poudel, Julie C. Stout, Phyllis Chua, Gary F. Egan, Jeffrey C.L. Looi, Nellie Georgiou-Karistianis

^*Corresponding author for this work

School of Medicine and Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Mapping the spatiotemporal progression of neuroanatomical change in Huntington's Disease (HD) is fundamental to the development of bio-measures for prognostication. Statistical shape analysis to measure the striatum has been performed in HD, however there have been a limited number of longitudinal studies. To address these limitations, we utilised the Spherical Harmonic Point Distribution Method (SPHARM-PDM) to generate point distribution models of the striatum in individuals, and used linear mixed models to test for localised shape change over time in pre-manifest HD (pre-HD), symp-HD (symp-HD) and control individuals. Longitudinal MRI scans from the IMAGE-HD study were used (baseline, 18 and 30 months). We found significant differences in the shape of the striatum between groups. Significant group-by-time interaction was observed for the putamen bilaterally, but not for caudate. A differential rate of shape change between groups over time was observed, with more significant deflation in the symp-HD group in comparison with the pre-HD and control groups. CAG repeats were correlated with bilateral striatal shape in pre-HD and symp-HD. Robust statistical analysis of the correlates of striatal shape change in HD has confirmed the suitability of striatal morphology as a potential biomarker correlated with CAG-repeat length, and potentially, an endophenotype.

Original language	English
Article number	111717
Journal	Psychiatry Research - Neuroimaging
Volume	335
DOIs	https://doi.org/10.1016/j.pscychresns.2023.111717
Publication status	Published - Oct 2023

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Wilkes, F. A., Jakabek, D., Walterfang, M., Velakoulis, D., Poudel, G. R., Stout, J. C., Chua, P., Egan, G. F., Looi, J. C. L., & Georgiou-Karistianis, N. (2023). The shape of things to come. Mapping spatiotemporal progression of striatal morphology in Huntington disease: The IMAGE-HD study. Psychiatry Research - Neuroimaging, 335, Article 111717. https://doi.org/10.1016/j.pscychresns.2023.111717

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title = "The shape of things to come. Mapping spatiotemporal progression of striatal morphology in Huntington disease: The IMAGE-HD study",

abstract = "Mapping the spatiotemporal progression of neuroanatomical change in Huntington's Disease (HD) is fundamental to the development of bio-measures for prognostication. Statistical shape analysis to measure the striatum has been performed in HD, however there have been a limited number of longitudinal studies. To address these limitations, we utilised the Spherical Harmonic Point Distribution Method (SPHARM-PDM) to generate point distribution models of the striatum in individuals, and used linear mixed models to test for localised shape change over time in pre-manifest HD (pre-HD), symp-HD (symp-HD) and control individuals. Longitudinal MRI scans from the IMAGE-HD study were used (baseline, 18 and 30 months). We found significant differences in the shape of the striatum between groups. Significant group-by-time interaction was observed for the putamen bilaterally, but not for caudate. A differential rate of shape change between groups over time was observed, with more significant deflation in the symp-HD group in comparison with the pre-HD and control groups. CAG repeats were correlated with bilateral striatal shape in pre-HD and symp-HD. Robust statistical analysis of the correlates of striatal shape change in HD has confirmed the suitability of striatal morphology as a potential biomarker correlated with CAG-repeat length, and potentially, an endophenotype.",

keywords = "Biomarker, Endophenotype, Huntington's disease, Striatum",

author = "Wilkes, {Fiona A.} and David Jakabek and Mark Walterfang and Dennis Velakoulis and Poudel, {Govinda R.} and Stout, {Julie C.} and Phyllis Chua and Egan, {Gary F.} and Looi, {Jeffrey C.L.} and Nellie Georgiou-Karistianis",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

month = oct,

doi = "10.1016/j.pscychresns.2023.111717",

language = "English",

volume = "335",

journal = "Psychiatry Research - Neuroimaging",

issn = "0925-4927",

publisher = "Elsevier Ireland Ltd",

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Wilkes, FA, Jakabek, D, Walterfang, M, Velakoulis, D, Poudel, GR, Stout, JC, Chua, P, Egan, GF, Looi, JCL & Georgiou-Karistianis, N 2023, 'The shape of things to come. Mapping spatiotemporal progression of striatal morphology in Huntington disease: The IMAGE-HD study', Psychiatry Research - Neuroimaging, vol. 335, 111717. https://doi.org/10.1016/j.pscychresns.2023.111717

TY - JOUR

T1 - The shape of things to come. Mapping spatiotemporal progression of striatal morphology in Huntington disease

T2 - The IMAGE-HD study

AU - Wilkes, Fiona A.

AU - Jakabek, David

AU - Walterfang, Mark

AU - Velakoulis, Dennis

AU - Poudel, Govinda R.

AU - Stout, Julie C.

AU - Chua, Phyllis

AU - Egan, Gary F.

AU - Looi, Jeffrey C.L.

AU - Georgiou-Karistianis, Nellie

PY - 2023/10

Y1 - 2023/10

N2 - Mapping the spatiotemporal progression of neuroanatomical change in Huntington's Disease (HD) is fundamental to the development of bio-measures for prognostication. Statistical shape analysis to measure the striatum has been performed in HD, however there have been a limited number of longitudinal studies. To address these limitations, we utilised the Spherical Harmonic Point Distribution Method (SPHARM-PDM) to generate point distribution models of the striatum in individuals, and used linear mixed models to test for localised shape change over time in pre-manifest HD (pre-HD), symp-HD (symp-HD) and control individuals. Longitudinal MRI scans from the IMAGE-HD study were used (baseline, 18 and 30 months). We found significant differences in the shape of the striatum between groups. Significant group-by-time interaction was observed for the putamen bilaterally, but not for caudate. A differential rate of shape change between groups over time was observed, with more significant deflation in the symp-HD group in comparison with the pre-HD and control groups. CAG repeats were correlated with bilateral striatal shape in pre-HD and symp-HD. Robust statistical analysis of the correlates of striatal shape change in HD has confirmed the suitability of striatal morphology as a potential biomarker correlated with CAG-repeat length, and potentially, an endophenotype.

AB - Mapping the spatiotemporal progression of neuroanatomical change in Huntington's Disease (HD) is fundamental to the development of bio-measures for prognostication. Statistical shape analysis to measure the striatum has been performed in HD, however there have been a limited number of longitudinal studies. To address these limitations, we utilised the Spherical Harmonic Point Distribution Method (SPHARM-PDM) to generate point distribution models of the striatum in individuals, and used linear mixed models to test for localised shape change over time in pre-manifest HD (pre-HD), symp-HD (symp-HD) and control individuals. Longitudinal MRI scans from the IMAGE-HD study were used (baseline, 18 and 30 months). We found significant differences in the shape of the striatum between groups. Significant group-by-time interaction was observed for the putamen bilaterally, but not for caudate. A differential rate of shape change between groups over time was observed, with more significant deflation in the symp-HD group in comparison with the pre-HD and control groups. CAG repeats were correlated with bilateral striatal shape in pre-HD and symp-HD. Robust statistical analysis of the correlates of striatal shape change in HD has confirmed the suitability of striatal morphology as a potential biomarker correlated with CAG-repeat length, and potentially, an endophenotype.

KW - Biomarker

KW - Endophenotype

KW - Huntington's disease

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=85171834693&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2023.111717

DO - 10.1016/j.pscychresns.2023.111717

M3 - Article

SN - 0925-4927

VL - 335

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

M1 - 111717

ER -

The shape of things to come. Mapping spatiotemporal progression of striatal morphology in Huntington disease: The IMAGE-HD study

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