The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background

Fleur Roberts; Amy V. Jennison; Naresh K. Verma

doi:10.1016/j.femsim.2005.05.002

The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background

Fleur Roberts, Amy V. Jennison, Naresh K. Verma^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Shigella flexneri is endemic in most developing countries and responsible for the highest mortality rate among the Shigella species. The attenuated serotype Y S. flexneri strain SFL124 has been used as the parental strain for the development of recombinant vaccines expressing multiple O-antigen structures. During the development of one such multivalent vaccine, a region of gtrII homology was found in SFL124. Sequencing and analysis of this region revealed the presence of an insertion element interrupted serotype 2a serotype-conversion locus in the serotype Y vaccine strain SFL124. The data presented suggests that SFL124 has derived from a serotype 2a background.

Original language	English
Pages (from-to)	285-289
Number of pages	5
Journal	FEMS Immunology and Medical Microbiology
Volume	45
Issue number	2
DOIs	https://doi.org/10.1016/j.femsim.2005.05.002
Publication status	Published - 1 Aug 2005

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10.1016/j.femsim.2005.05.002

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title = "The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background",

abstract = "Shigella flexneri is endemic in most developing countries and responsible for the highest mortality rate among the Shigella species. The attenuated serotype Y S. flexneri strain SFL124 has been used as the parental strain for the development of recombinant vaccines expressing multiple O-antigen structures. During the development of one such multivalent vaccine, a region of gtrII homology was found in SFL124. Sequencing and analysis of this region revealed the presence of an insertion element interrupted serotype 2a serotype-conversion locus in the serotype Y vaccine strain SFL124. The data presented suggests that SFL124 has derived from a serotype 2a background.",

keywords = "Glucosyl transferases, Serotype reversion, Shigella flexneri",

author = "Fleur Roberts and Jennison, \{Amy V.\} and Verma, \{Naresh K.\}",

year = "2005",

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doi = "10.1016/j.femsim.2005.05.002",

language = "English",

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pages = "285--289",

journal = "FEMS Immunology and Medical Microbiology",

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T1 - The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background

AU - Roberts, Fleur

AU - Jennison, Amy V.

AU - Verma, Naresh K.

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Shigella flexneri is endemic in most developing countries and responsible for the highest mortality rate among the Shigella species. The attenuated serotype Y S. flexneri strain SFL124 has been used as the parental strain for the development of recombinant vaccines expressing multiple O-antigen structures. During the development of one such multivalent vaccine, a region of gtrII homology was found in SFL124. Sequencing and analysis of this region revealed the presence of an insertion element interrupted serotype 2a serotype-conversion locus in the serotype Y vaccine strain SFL124. The data presented suggests that SFL124 has derived from a serotype 2a background.

AB - Shigella flexneri is endemic in most developing countries and responsible for the highest mortality rate among the Shigella species. The attenuated serotype Y S. flexneri strain SFL124 has been used as the parental strain for the development of recombinant vaccines expressing multiple O-antigen structures. During the development of one such multivalent vaccine, a region of gtrII homology was found in SFL124. Sequencing and analysis of this region revealed the presence of an insertion element interrupted serotype 2a serotype-conversion locus in the serotype Y vaccine strain SFL124. The data presented suggests that SFL124 has derived from a serotype 2a background.

KW - Glucosyl transferases

KW - Serotype reversion

KW - Shigella flexneri

UR - https://www.scopus.com/pages/publications/22844452320

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DO - 10.1016/j.femsim.2005.05.002

M3 - Article

SN - 0928-8244

VL - 45

SP - 285

EP - 289

JO - FEMS Immunology and Medical Microbiology

JF - FEMS Immunology and Medical Microbiology

IS - 2

ER -

The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background

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