The signature of somatic hypermutation appears to be written into the germline IgV segment repertoire

Robert V. Blanden; Harald S. Rothenfluh; Paula Zylstra; Georg F. Weiller; Edward J. Steele

doi:10.1111/j.1600-065X.1998.tb01435.x

The signature of somatic hypermutation appears to be written into the germline IgV segment repertoire

Robert V. Blanden, Harald S. Rothenfluh, Paula Zylstra, Georg F. Weiller, Edward J. Steele^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

We present here a unifying hypothesis for the molecular mechanism of somatic hypermutation and somatic gene conversion in IgV genes involving reverse transcription using RNA templates from the V-gene loci to produce cDNA which undergoes homologous recombination with chromosomal V(D)J DNA. Experimental evidence produced over the last 20 years is essentially consistent with this hypothesis. We also review evidence suggesting that somatically generated IgV sequences from Blymphocytes have been fed back to germline DNA over evolutionary time.

Original language	English
Pages (from-to)	117-132
Number of pages	16
Journal	Immunological Reviews
Volume	162
DOIs	https://doi.org/10.1111/j.1600-065X.1998.tb01435.x
Publication status	Published - Apr 1998

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10.1111/j.1600-065X.1998.tb01435.x

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AU - Steele, Edward J.

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The signature of somatic hypermutation appears to be written into the germline IgV segment repertoire

Abstract

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