The significance of regional metastasis location in head and neck cutaneous squamous cell carcinoma

Craig P. Mooney; Jonathan R. Clark; Kerwin Shannon; Carsten E. Palme; Ardalan Ebrahimi; Kan Gao; Sydney Ch'ng; Michael Elliott; Ruta Gupta; Tsu Hui Low

doi:10.1002/hed.26744

The significance of regional metastasis location in head and neck cutaneous squamous cell carcinoma

Craig P. Mooney^*, Jonathan R. Clark, Kerwin Shannon, Carsten E. Palme, Ardalan Ebrahimi, Kan Gao, Sydney Ch'ng, Michael Elliott, Ruta Gupta, Tsu Hui Low

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Background: Regional metastasis of head and neck cutaneous squamous cell carcinoma (HNcSCC) can be seen in either parotid and/or cervical lymph nodes. The aim of this study was to assess whether there was a difference in prognosis between parotid and cervical nodal metastases. Methods: Patients with regional metastasis from HNcSCC were identified from an institutional database. Disease-specific (DSS) and overall survival (OS) were calculated using the Kaplan–Meier method and Cox proportional hazards models. Results: Five hundred and thirty-five patients were identified with median follow-up of 26.4 months (3–255 months). Two hundred and thirty-five patients had parotid metastasis, 96 patients had neck metastasis, and 204 patients had both. On multivariable analysis, any regional metastasis to the neck when compared to parotid alone conferred worse DSS (HR 1.8, p = 0.007) and OS (HR 1.3, p = 0.024). Conclusion: Regional metastasis of HNcSCC to the neck confers worse outcomes compared to metastasis to the parotid alone.

Original language	English
Pages (from-to)	2705-2711
Number of pages	7
Journal	Head and Neck
Volume	43
Issue number	9
DOIs	https://doi.org/10.1002/hed.26744
Publication status	Published - Sept 2021

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@article{29cd40e8cb324f12b6808b17f0690165,

title = "The significance of regional metastasis location in head and neck cutaneous squamous cell carcinoma",

abstract = "Background: Regional metastasis of head and neck cutaneous squamous cell carcinoma (HNcSCC) can be seen in either parotid and/or cervical lymph nodes. The aim of this study was to assess whether there was a difference in prognosis between parotid and cervical nodal metastases. Methods: Patients with regional metastasis from HNcSCC were identified from an institutional database. Disease-specific (DSS) and overall survival (OS) were calculated using the Kaplan–Meier method and Cox proportional hazards models. Results: Five hundred and thirty-five patients were identified with median follow-up of 26.4 months (3–255 months). Two hundred and thirty-five patients had parotid metastasis, 96 patients had neck metastasis, and 204 patients had both. On multivariable analysis, any regional metastasis to the neck when compared to parotid alone conferred worse DSS (HR 1.8, p = 0.007) and OS (HR 1.3, p = 0.024). Conclusion: Regional metastasis of HNcSCC to the neck confers worse outcomes compared to metastasis to the parotid alone.",

keywords = "head and neck cancer, metastasis, parotid cancer, skin cancer, squamous cell cancer",

author = "Mooney, {Craig P.} and Clark, {Jonathan R.} and Kerwin Shannon and Palme, {Carsten E.} and Ardalan Ebrahimi and Kan Gao and Sydney Ch'ng and Michael Elliott and Ruta Gupta and Low, {Tsu Hui}",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",

year = "2021",

month = sep,

doi = "10.1002/hed.26744",

language = "English",

volume = "43",

pages = "2705--2711",

journal = "Head and Neck",

issn = "1043-3074",

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TY - JOUR

T1 - The significance of regional metastasis location in head and neck cutaneous squamous cell carcinoma

AU - Mooney, Craig P.

AU - Clark, Jonathan R.

AU - Shannon, Kerwin

AU - Palme, Carsten E.

AU - Ebrahimi, Ardalan

AU - Gao, Kan

AU - Ch'ng, Sydney

AU - Elliott, Michael

AU - Gupta, Ruta

AU - Low, Tsu Hui

PY - 2021/9

Y1 - 2021/9

N2 - Background: Regional metastasis of head and neck cutaneous squamous cell carcinoma (HNcSCC) can be seen in either parotid and/or cervical lymph nodes. The aim of this study was to assess whether there was a difference in prognosis between parotid and cervical nodal metastases. Methods: Patients with regional metastasis from HNcSCC were identified from an institutional database. Disease-specific (DSS) and overall survival (OS) were calculated using the Kaplan–Meier method and Cox proportional hazards models. Results: Five hundred and thirty-five patients were identified with median follow-up of 26.4 months (3–255 months). Two hundred and thirty-five patients had parotid metastasis, 96 patients had neck metastasis, and 204 patients had both. On multivariable analysis, any regional metastasis to the neck when compared to parotid alone conferred worse DSS (HR 1.8, p = 0.007) and OS (HR 1.3, p = 0.024). Conclusion: Regional metastasis of HNcSCC to the neck confers worse outcomes compared to metastasis to the parotid alone.

AB - Background: Regional metastasis of head and neck cutaneous squamous cell carcinoma (HNcSCC) can be seen in either parotid and/or cervical lymph nodes. The aim of this study was to assess whether there was a difference in prognosis between parotid and cervical nodal metastases. Methods: Patients with regional metastasis from HNcSCC were identified from an institutional database. Disease-specific (DSS) and overall survival (OS) were calculated using the Kaplan–Meier method and Cox proportional hazards models. Results: Five hundred and thirty-five patients were identified with median follow-up of 26.4 months (3–255 months). Two hundred and thirty-five patients had parotid metastasis, 96 patients had neck metastasis, and 204 patients had both. On multivariable analysis, any regional metastasis to the neck when compared to parotid alone conferred worse DSS (HR 1.8, p = 0.007) and OS (HR 1.3, p = 0.024). Conclusion: Regional metastasis of HNcSCC to the neck confers worse outcomes compared to metastasis to the parotid alone.

KW - head and neck cancer

KW - metastasis

KW - parotid cancer

KW - skin cancer

KW - squamous cell cancer

UR - http://www.scopus.com/inward/record.url?scp=85106249239&partnerID=8YFLogxK

U2 - 10.1002/hed.26744

DO - 10.1002/hed.26744

M3 - Article

SN - 1043-3074

VL - 43

SP - 2705

EP - 2711

JO - Head and Neck

JF - Head and Neck

IS - 9

ER -

The significance of regional metastasis location in head and neck cutaneous squamous cell carcinoma

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