The solute carrier 6 family of transporters

Stefan Bröer; Ulrik Gether

doi:10.1111/j.1476-5381.2012.01975.x

The solute carrier 6 family of transporters

Stefan Bröer^*
, Ulrik Gether

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

221 Citations (Scopus)

Abstract

The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.

Original language	English
Pages (from-to)	256-278
Number of pages	23
Journal	British Journal of Pharmacology
Volume	167
Issue number	2
DOIs	https://doi.org/10.1111/j.1476-5381.2012.01975.x
Publication status	Published - Sept 2012

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10.1111/j.1476-5381.2012.01975.x

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AB - The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.

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KW - monoamine transporters

KW - transport mechanism

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DO - 10.1111/j.1476-5381.2012.01975.x

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The solute carrier 6 family of transporters

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