The structure of the homeodomain and its functional implications

W. J. Gehring; M. Müller; M. Affolter; A. Percival-Smith; M. Billeter; Y. Q. Qian; G. Otting; K. Wüthrich

doi:10.1016/0168-9525(90)90253-3

The structure of the homeodomain and its functional implications

W. J. Gehring^*, M. Müller, M. Affolter, A. Percival-Smith, M. Billeter, Y. Q. Qian, G. Otting, K. Wüthrich

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

221 Citations (Scopus)

Abstract

The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.

Original language	English
Pages (from-to)	323-329
Number of pages	7
Journal	Trends in Genetics
Volume	6
Issue number	C
DOIs	https://doi.org/10.1016/0168-9525(90)90253-3
Publication status	Published - 1990
Externally published	Yes

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title = "The structure of the homeodomain and its functional implications",

abstract = "The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.",

author = "Gehring, \{W. J.\} and M. M{\"u}ller and M. Affolter and A. Percival-Smith and M. Billeter and Qian, \{Y. Q.\} and G. Otting and K. W{\"u}thrich",

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T1 - The structure of the homeodomain and its functional implications

AU - Gehring, W. J.

AU - Müller, M.

AU - Affolter, M.

AU - Percival-Smith, A.

AU - Billeter, M.

AU - Qian, Y. Q.

AU - Otting, G.

AU - Wüthrich, K.

PY - 1990

Y1 - 1990

N2 - The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.

AB - The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.

UR - https://www.scopus.com/pages/publications/0025008350

U2 - 10.1016/0168-9525(90)90253-3

DO - 10.1016/0168-9525(90)90253-3

M3 - Article

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AN - SCOPUS:0025008350

SN - 0168-9525

VL - 6

SP - 323

EP - 329

JO - Trends in Genetics

JF - Trends in Genetics

IS - C

ER -

The structure of the homeodomain and its functional implications

Abstract

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