The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer

Elizabeth P. Murchison; Cesar Tovar; Arthur Hsu; Hannah S. Bender; Pouya Kheradpour; Clare A. Rebbeck; David Obendorf; Carly Conlan; Melanie Bahlo; Catherine A. Blizzard; Stephen Pyecroft; Alexandre Kreiss; Manolis Kellis; Alexander Stark; Timothy T. Harkins; Jennifer A. Marshall Graves; Gregory M. Woods; Gregory J. Hannon; Anthony T. Papenfuss

doi:10.1126/science.1180616

The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer

Elizabeth P. Murchison, Cesar Tovar, Arthur Hsu, Hannah S. Bender, Pouya Kheradpour, Clare A. Rebbeck, David Obendorf, Carly Conlan, Melanie Bahlo, Catherine A. Blizzard, Stephen Pyecroft, Alexandre Kreiss, Manolis Kellis, Alexander Stark, Timothy T. Harkins, Jennifer A. Marshall Graves, Gregory M. Woods, Gregory J. Hannon, Anthony T. Papenfuss

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193 Citations (Scopus)

Abstract

The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.

Original language	English
Pages (from-to)	84-87
Number of pages	4
Journal	Science
Volume	327
Issue number	5961
DOIs	https://doi.org/10.1126/science.1180616
Publication status	Published - 1 Jan 2010

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Murchison, E. P., Tovar, C., Hsu, A., Bender, H. S., Kheradpour, P., Rebbeck, C. A., Obendorf, D., Conlan, C., Bahlo, M., Blizzard, C. A., Pyecroft, S., Kreiss, A., Kellis, M., Stark, A., Harkins, T. T., Marshall Graves, J. A., Woods, G. M., Hannon, G. J., & Papenfuss, A. T. (2010). The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer. Science, 327(5961), 84-87. https://doi.org/10.1126/science.1180616

@article{a91d5c6100134053a82f4b727120e894,

title = "The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer",

abstract = "The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.",

author = "Murchison, {Elizabeth P.} and Cesar Tovar and Arthur Hsu and Bender, {Hannah S.} and Pouya Kheradpour and Rebbeck, {Clare A.} and David Obendorf and Carly Conlan and Melanie Bahlo and Blizzard, {Catherine A.} and Stephen Pyecroft and Alexandre Kreiss and Manolis Kellis and Alexander Stark and Harkins, {Timothy T.} and {Marshall Graves}, {Jennifer A.} and Woods, {Gregory M.} and Hannon, {Gregory J.} and Papenfuss, {Anthony T.}",

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doi = "10.1126/science.1180616",

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Murchison, EP, Tovar, C, Hsu, A, Bender, HS, Kheradpour, P, Rebbeck, CA, Obendorf, D, Conlan, C, Bahlo, M, Blizzard, CA, Pyecroft, S, Kreiss, A, Kellis, M, Stark, A, Harkins, TT, Marshall Graves, JA, Woods, GM, Hannon, GJ & Papenfuss, AT 2010, 'The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer', Science, vol. 327, no. 5961, pp. 84-87. https://doi.org/10.1126/science.1180616

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T1 - The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer

AU - Murchison, Elizabeth P.

AU - Tovar, Cesar

AU - Hsu, Arthur

AU - Bender, Hannah S.

AU - Kheradpour, Pouya

AU - Rebbeck, Clare A.

AU - Obendorf, David

AU - Conlan, Carly

AU - Bahlo, Melanie

AU - Blizzard, Catherine A.

AU - Pyecroft, Stephen

AU - Kreiss, Alexandre

AU - Kellis, Manolis

AU - Stark, Alexander

AU - Harkins, Timothy T.

AU - Marshall Graves, Jennifer A.

AU - Woods, Gregory M.

AU - Hannon, Gregory J.

AU - Papenfuss, Anthony T.

PY - 2010/1/1

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JO - Science

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IS - 5961

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The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer

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