The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer

Elizabeth P. Murchison; Cesar Tovar; Arthur Hsu; Hannah S. Bender; Pouya Kheradpour; Clare A. Rebbeck; David Obendorf; Carly Conlan; Melanie Bahlo; Catherine A. Blizzard; Stephen Pyecroft; Alexandre Kreiss; Manolis Kellis; Alexander Stark; Timothy T. Harkins; Jennifer A. Marshall Graves; Gregory M. Woods; Gregory J. Hannon; Anthony T. Papenfuss

doi:10.1126/science.1180616

The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer

Elizabeth P. Murchison
, Cesar Tovar
, Arthur Hsu
, Hannah S. Bender
, Pouya Kheradpour
, Clare A. Rebbeck
, David Obendorf
, Carly Conlan
, Melanie Bahlo
, Catherine A. Blizzard
, Stephen Pyecroft
, Alexandre Kreiss
, Manolis Kellis
, Alexander Stark
, Timothy T. Harkins
, Jennifer A. Marshall Graves
, Gregory M. Woods
, Gregory J. Hannon
, Anthony T. Papenfuss

Research output: Contribution to journal › Article › peer-review

201 Citations (Scopus)

Abstract

The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.

Original language	English
Pages (from-to)	84-87
Number of pages	4
Journal	Science
Volume	327
Issue number	5961
DOIs	https://doi.org/10.1126/science.1180616
Publication status	Published - 1 Jan 2010

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Murchison, E. P., Tovar, C., Hsu, A., Bender, H. S., Kheradpour, P., Rebbeck, C. A., Obendorf, D., Conlan, C., Bahlo, M., Blizzard, C. A., Pyecroft, S., Kreiss, A., Kellis, M., Stark, A., Harkins, T. T., Marshall Graves, J. A., Woods, G. M., Hannon, G. J., & Papenfuss, A. T. (2010). The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer. Science, 327(5961), 84-87. https://doi.org/10.1126/science.1180616

@article{a91d5c6100134053a82f4b727120e894,

title = "The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer",

abstract = "The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.",

author = "Murchison, \{Elizabeth P.\} and Cesar Tovar and Arthur Hsu and Bender, \{Hannah S.\} and Pouya Kheradpour and Rebbeck, \{Clare A.\} and David Obendorf and Carly Conlan and Melanie Bahlo and Blizzard, \{Catherine A.\} and Stephen Pyecroft and Alexandre Kreiss and Manolis Kellis and Alexander Stark and Harkins, \{Timothy T.\} and \{Marshall Graves\}, \{Jennifer A.\} and Woods, \{Gregory M.\} and Hannon, \{Gregory J.\} and Papenfuss, \{Anthony T.\}",

year = "2010",

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doi = "10.1126/science.1180616",

language = "English",

volume = "327",

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journal = "Science",

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Murchison, EP, Tovar, C, Hsu, A, Bender, HS, Kheradpour, P, Rebbeck, CA, Obendorf, D, Conlan, C, Bahlo, M, Blizzard, CA, Pyecroft, S, Kreiss, A, Kellis, M, Stark, A, Harkins, TT, Marshall Graves, JA, Woods, GM, Hannon, GJ & Papenfuss, AT 2010, 'The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer', Science, vol. 327, no. 5961, pp. 84-87. https://doi.org/10.1126/science.1180616

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T1 - The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer

AU - Murchison, Elizabeth P.

AU - Tovar, Cesar

AU - Hsu, Arthur

AU - Bender, Hannah S.

AU - Kheradpour, Pouya

AU - Rebbeck, Clare A.

AU - Obendorf, David

AU - Conlan, Carly

AU - Bahlo, Melanie

AU - Blizzard, Catherine A.

AU - Pyecroft, Stephen

AU - Kreiss, Alexandre

AU - Kellis, Manolis

AU - Stark, Alexander

AU - Harkins, Timothy T.

AU - Marshall Graves, Jennifer A.

AU - Woods, Gregory M.

AU - Hannon, Gregory J.

AU - Papenfuss, Anthony T.

PY - 2010/1/1

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N2 - The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.

AB - The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.

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VL - 327

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JO - Science

JF - Science

IS - 5961

ER -

The Tasmanian devil transcriptome reveals schwann cell origins of a clonally transmissible cancer

Abstract

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