The use of fixed study main effects in arm-based network meta-analysis

Hans Peter Piepho; Laurence V. Madden; Emlyn R. Williams

doi:10.1002/jrsm.1721

The use of fixed study main effects in arm-based network meta-analysis

Hans Peter Piepho^*, Laurence V. Madden, Emlyn R. Williams

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

4 Citations (Scopus)

Abstract

Methods of network meta-analysis (NMA) can be classified as arm-based and contrast-based approaches. There are several arm-based approaches, and some of these have been criticized because they recover inter-study information and hence do not obey the principle of concurrent control. Here, we point out that recovery of inter-study information in arm-based NMA can be prevented by fitting a fixed main effect for studies. Advantages of arm-based NMA are discussed.

Original language	English
Number of pages	4
Journal	Research Synthesis Methods
DOIs	https://doi.org/10.1002/jrsm.1721
Publication status	Published - 9 May 2024

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10.1002/jrsm.1721

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abstract = "Methods of network meta-analysis (NMA) can be classified as arm-based and contrast-based approaches. There are several arm-based approaches, and some of these have been criticized because they recover inter-study information and hence do not obey the principle of concurrent control. Here, we point out that recovery of inter-study information in arm-based NMA can be prevented by fitting a fixed main effect for studies. Advantages of arm-based NMA are discussed.",

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AU - Piepho, Hans Peter

AU - Madden, Laurence V.

AU - Williams, Emlyn R.

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Y1 - 2024/5/9

N2 - Methods of network meta-analysis (NMA) can be classified as arm-based and contrast-based approaches. There are several arm-based approaches, and some of these have been criticized because they recover inter-study information and hence do not obey the principle of concurrent control. Here, we point out that recovery of inter-study information in arm-based NMA can be prevented by fitting a fixed main effect for studies. Advantages of arm-based NMA are discussed.

AB - Methods of network meta-analysis (NMA) can be classified as arm-based and contrast-based approaches. There are several arm-based approaches, and some of these have been criticized because they recover inter-study information and hence do not obey the principle of concurrent control. Here, we point out that recovery of inter-study information in arm-based NMA can be prevented by fitting a fixed main effect for studies. Advantages of arm-based NMA are discussed.

KW - incomplete block design

KW - inter-block information

KW - inter-study information

KW - recovery of information

KW - residual maximum likelihood

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U2 - 10.1002/jrsm.1721

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M3 - Comment/debate

AN - SCOPUS:85192525230

SN - 1759-2879

JO - Research Synthesis Methods

JF - Research Synthesis Methods

ER -

The use of fixed study main effects in arm-based network meta-analysis

Abstract

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